|Title:||Method of providing an antihistaminic effect in a hepatically impaired patient|
|Abstract:||The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2; n is an integer of from 1 to 5; R.sub.3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen; or a pharmaceutically acceptable salt and individual isomers thereof.|
|Inventor(s):||Woodward; James K. (Cincinnati, OH), Okerholm; Richard A. (West Chester, OH), Eller; Mark G. (Overland Park, KS), McNutt; Bruce E. (Olathe, KS)|
|Assignee:||Merrell Pharmaceuticals Inc. (Bridgewater, NJ)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|World Intellectual Property Organization (WIPO)||9323047||Nov 25, 1993|
|United States of America||2003130315||Jul 10, 2003|
|United States of America||6037353||Mar 14, 2000|
|United States of America||2006205782||Sep 14, 2006|
|United States of America||2010168166||Jul 01, 2010|
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