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|Title:||Multivesicular liposomes with controlled release of encapsulated biologically active substances|
|Abstract:||A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.|
|Inventor(s):||Sankaram; Mantripragada Bhima (San Diego, CA), Kim; Sinil (Solana Beach, CA)|
|Assignee:||SkyePharma Inc. (San Diego, CA)|
Patent Claim Types:|
see list of patent claims
|Use; Dosage form; Device;|
|Country||Document Number||Publication Date|
|Austria||196248||Sep 15, 2000|
|Australia||1053595||Jun 06, 1995|
|Australia||686277||Feb 05, 1998|
|Bulgaria||63146||May 31, 2001|
|Bulgaria||100596||Dec 31, 1996|
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