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|Title:||Pharmaceutical compositions in semisolid form and a device for administration thereof|
|Abstract:||A pharmaceutical delivery system for oral administration of a pharmaceutical agent comprises: (a) a squeezable container having an outlet defining a flow channel, (b) a channel closure device adapted to selectively close or open the flow channel; and (c) within the container, at least one dose of a pharmaceutical composition, the composition being a semisolid material that is storage stable, and consists of mutually compatible components, the components comprising (i) an effective amount of an orally active pharmaceutical agent useful for systemic treatment, and (ii) a palatable pharmaceutically acceptable vehicle, comprising a liquid base selected from the group consisting of water, propylene glycol, polyethylene glycol, glycerin, and mixtures thereof, a thickening agent selected from the group consisting of starch, modified starch, sodium carboxymethyl cellulose, microcrystalline cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, other cellulose derivatives, acacia, tragacanth, pectin, gelatin, polyethylene glycol, and water-soluble carboxyvinyl polymers, the pharmaceutical composition having a consistency which allows the composition to be squeezed by manual pressure through the flow channel, whereby in response to pressure on the container when the flow channel is open, a predetermined unit dose of the pharmaceutical composition can be easily squeezed from the container into a receptacle, measured, and administered orally without spilling any of the composition from the container or the receptacle.|
|Inventor(s):||Ross; Malcolm Stewart Frank (Tel Aviv, IL)|
|Assignee:||Taro Pharmaceutical Industies Ltd. (Haifa Bay, IL)|
Patent Claim Types:|
see list of patent claims
|Dosage form; Delivery; Device; Composition; Use; Formulation;|
|Country||Document Number||Publication Date|
|South Africa||9401002||Sep 30, 1994|
|United States of America||5881926||Mar 16, 1999|
|Japan||7010743||Jan 13, 1995|
|Japan||3417991||Jun 16, 2003|
|Israel||108366||Apr 12, 1994|
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