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|Abstract:||Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.|
|Inventor(s):||Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|South Africa||9308620||Aug 04, 1994|
|World Intellectual Property Organization (WIPO)||9411387||May 26, 1994|
|United States of America||5468860||Nov 21, 1995|
|United States of America||5652365||Jul 29, 1997|
|Taiwan||257766||Sep 21, 1995|
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