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Details for Patent: 5,886,184

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Patent 5,886,184 protects and is included in zero NDA.

Summary for Patent: 5,886,184

Title: Finasteride processes
Abstract:Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
Inventor(s): Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:08/824,426
Patent Claim Types:
see list of patent claims
Compound; Process;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,886,184

Country Document Number Publication Date
South Africa9308620Aug 04, 1994
World Intellectual Property Organization (WIPO)9411387May 26, 1994
United States of America5468860Nov 21, 1995
United States of America5652365Jul 29, 1997
Taiwan257766Sep 21, 1995
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