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Details for Patent: 5,886,184

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Summary for Patent: 5,886,184

Title: Finasteride processes
Abstract:Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
Inventor(s): Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:08/824,426
Patent Claim Types:
see list of patent claims
Compound; Process;
Patent Metrics:
Source: PatentStat.com
Field: Organic fine chemistry
Back Citations: 16
Forward Citations: 1
Patent PDF download available with subscription

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International Patent Family for Patent: 5,886,184

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
JapanH06199889Jul 19, 1994
Poland179379Aug 31, 2000
Finland20010290Feb 15, 2001
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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