Details for Patent: 5,824,642
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Summary for Patent: 5,824,642
Title: | Treatment of partial growth hormone insensitivity syndrome |
Abstract: | Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering an effective dose of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, a serum level of high-affinity growth hormone binding protein that is at least 2 standard deviations below normal levels, a serum level of IGF-I that is below normal mean levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I, given alone or in combination with an amount of growth hormone that is effective in combination with the IGF-I. |
Inventor(s): | Attie; Kenneth (San Francisco, CA), Carlsson; Lena M. S. (Goteborg, SE), Gesundheit; Neil (Los Altos, CA), Goddard; Audrey (San Francisco, CA) |
Assignee: | Genentech, Inc. (South San Francisco, CA) |
Application Number: | 08/468,580 |
Patent Claim Types: see list of patent claims | Use; |
Drugs Protected by US Patent 5,824,642
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International Family Members for US Patent 5,824,642
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Austria | 203165 | ⤷ Try a Trial | |||
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Canada | 2187274 | ⤷ Try a Trial | |||
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Germany | 69521796 | ⤷ Try a Trial | |||
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