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Details for Patent: 5,716,640

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Summary for Patent: 5,716,640

Title: Method of producing sustained-release microcapsules
Abstract:A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.
Inventor(s): Kamei; Shigeru (Takarazuka, JP), Yamada; Minoru (Kawanishi, JP), Ogawa; Yasuaki (Ohyamazaki-cho, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/705,348
Patent Claim Types:
see list of patent claims
Use; Dosage form;
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,716,640

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan4-234821Sep 02, 1992

International Patent Family for Patent: 5,716,640

Country Document Number Publication Date
United States of America5575987Nov 19, 1996
Japan6192068Jul 12, 1994
Japan3277342Apr 22, 2002
Greece3029508May 28, 1999
Spain2125953Mar 16, 1999
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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