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|Title:||Method of producing sustained-release microcapsules|
|Abstract:||A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.|
|Inventor(s):||Kamei; Shigeru (Takarazuka, JP), Yamada; Minoru (Kawanishi, JP), Ogawa; Yasuaki (Ohyamazaki-cho, JP)|
|Assignee:||Takeda Chemical Industries, Ltd. (Osaka, JP)|
Patent Claim Types:|
see list of patent claims
|Use; Dosage form;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|Japan||4-234821||Sep 02, 1992|
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Denmark||0586238||Aug 30, 1999|
|European Patent Office||0586238||Jan 07, 1999|
|European Patent Office||0586238||Jun 29, 1994|
|Austria||175345||Jan 15, 1999|
|Spain||2125953||Mar 16, 1999|
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