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Details for Patent: 5,716,640

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Summary for Patent: 5,716,640

Title: Method of producing sustained-release microcapsules
Abstract:A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.
Inventor(s): Kamei; Shigeru (Takarazuka, JP), Yamada; Minoru (Kawanishi, JP), Ogawa; Yasuaki (Ohyamazaki-cho, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/705,348
Patent Claim Types:
see list of patent claims
Use; Dosage form;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020011Oct 22, 1990DISCNNo5,716,640<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION019732Jan 26, 1989RXYes5,716,640<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020708Mar 7, 1997RXYes5,716,640<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020517Dec 22, 1995RXYes5,716,640<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020517May 30, 1997RXYes5,716,640<disabled>
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Foreign Priority and PCT Information for Patent: 5,716,640

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan4-234821Sep 02, 1992

International Patent Family for Patent: 5,716,640

Country Document Number Publication Date
5575987Nov 19, 1996
Japan6192068Jul 12, 1994
Japan3277342Apr 22, 2002
Greece3029508May 28, 1999
Spain2125953Mar 16, 1999
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