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Details for Patent: 5,656,297

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Summary for Patent: 5,656,297

Title: Modulated release from biocompatible polymers
Abstract:The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.
Inventor(s): Bernstein; Howard (Cambridge, MA), Zhang; Yan (Cambridge, MA), Khan; M. Amin (Downingtown, PA), Tracy; Mark A. (Arlington, MA)
Assignee: Alkermes Controlled Therapeutics, Incorporated (Cambridge, MA)
Application Number:08/237,057
Patent Claim Types:
see list of patent claims
Composition; Use; Formulation;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,656,297

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office0758227Jan 14, 2004
World Intellectual Property Organization (WIPO)9529664Nov 09, 1995
Austria154240Jun 15, 1997
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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