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Details for Patent: 5,656,297

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Patent 5,656,297 protects NUTROPIN DEPOT and is included in one NDA.

This patent has expired prematurely due to non-payment of maintenance fees. See details below.

Summary for Patent: 5,656,297

Title: Modulated release from biocompatible polymers
Abstract:The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.
Inventor(s): Bernstein; Howard (Cambridge, MA), Zhang; Yan (Cambridge, MA), Khan; M. Amin (Downingtown, PA), Tracy; Mark A. (Arlington, MA)
Assignee: Alkermes Controlled Therapeutics, Incorporated (Cambridge, MA)
Application Number:08/237,057
Patent Claim Types:
see list of patent claims
Composition; Use; Formulation;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Genentech
NUTROPIN DEPOT
somatropin recombinant
INJECTABLE;INJECTION021075Dec 22, 1999DISCNNo5,656,297<disabled>
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Premature patent expiration for: 5,656,297

Expiration due to failure to pay maintenance fee
Patent Number:5,656,297 Tradename:
NUTROPIN DEPOT
Expiration Date:August 12, 2009

International Patent Family for Patent: 5,656,297

Country Document Number Publication Date
World Intellectual Property Organization (WIPO)9317668Sep 16, 1993
World Intellectual Property Organization (WIPO)9529664Nov 09, 1995
United States of America5413797May 09, 1995
United States of America5912015Jun 15, 1999
United States of America6368630Apr 09, 2002
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