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Details for Patent: 5,656,297

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Summary for Patent: 5,656,297

Title: Modulated release from biocompatible polymers
Abstract:The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.
Inventor(s): Bernstein; Howard (Cambridge, MA), Zhang; Yan (Cambridge, MA), Khan; M. Amin (Downingtown, PA), Tracy; Mark A. (Arlington, MA)
Assignee: Alkermes Controlled Therapeutics, Incorporated (Cambridge, MA)
Application Number:08/237,057
Patent Claim Types:
see list of patent claims
Composition; Use; Formulation;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Genentech
NUTROPIN DEPOT
somatropin recombinant
INJECTABLE;INJECTION021075Dec 22, 1999DISCNNo5,656,297<disabled>
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Patent activity for: 5,656,297

Failure to pay maintenance fee
Patent Number:5,656,297 Application Number:08/237,057 Issue Date:Aug 12 1997 Expiration Date:Aug 12 2009
Failure to pay maintenance fee
Patent Number:5,656,297 Application Number:08/237,057 Issue Date:Aug 12 1997 Expiration Date:Aug 12 2009

International Patent Family for Patent: 5,656,297

Country Document Number Publication Date
9317668Sep 16, 1993
9529664Nov 09, 1995
2002168410Nov 14, 2002
6749866Jun 15, 2004
5912015Jun 15, 1999
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