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Details for Patent: 5,645,815

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Patent 5,645,815 protects ACUTECT and is included in one NDA.

This patent has two hundred and forty-five patent family members in twenty-five countries.

This patent has expired prematurely due to non-payment of maintenance fees. See details below.

Summary for Patent: 5,645,815

Title: Radiolabled compounds for thrombus imaging
Abstract:This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.
Inventor(s): Dean; Richard T. (Bedford, NH), Lister-James; John (Bedford, NH), Civitello; Edgar R. (Bradford, NH)
Assignee: Diatide, Inc. (Londonderry, NH)
Application Number:08/439,905
Patent Claim Types:
see list of patent claims
Compound; Composition; Device; Use;
Patent PDF download available with subscription

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Cis Bio Intl Sa
technetium tc-99m apcitide
INJECTABLE;INJECTION020887-001Sep 14, 1998DISCNNo5,645,815<disabled>
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Premature patent expiration for: 5,645,815

Expiration due to failure to pay maintenance fee

Patent Number Tradename Expiration Date
July 08, 2009

Non-Orange Book Patents for Patent: 5,645,815

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
5,922,303 Technetium-99M labeled peptides for imaging<disabled in preview>
5,993,775 Radioactively labeled peptides comprising a single thiol moiety<disabled in preview>
5,972,308 Peptide-metal chelate conjugates<disabled in preview>
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International Patent Family for Patent: 5,645,815

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Japan3117218Dec 11, 2000
Australia3276093Jun 28, 1993
Canada2195395Feb 15, 1996
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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