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Details for Patent: 5,639,738

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Summary for Patent: 5,639,738

Title: Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
Abstract:A method of treating a mammal for a condition of the skin or exposed tissue selected from the group consisting of basal cell carcinoma and actinic keratosis is provided. The method consists essentially of topically administering to the site of the condition, more than once per day over a period of days sufficient to treat the condition, a non-toxic effective dosage amount of a composition consisting essentially of (a) a non-steroidal anti-inflammatory drug (NSAID) in an amount sufficient to block prostaglandin synthesis, (b) hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount effective to transport said NSAID into the skin or exposed tissue at the site of the condition. The concentration of the hyaluronic add or salt thereof is between 1-3% by weight of the composition. The molecular weight of the hyaluronic acid or salt thereof is between 150,000 and 750,000 Daltons. A pharmaceutical excipient suitable for topical application is included. The NSAID in the composition may be diclofenac sodium.
Inventor(s): Falk; Rudolf Edgar (Toronto, CA), Asculai; Samuel Simon (Toronto, CA)
Assignee: Hyal Pharmaceutical Corporation (Mississauga, CA)
Application Number:07/838,675
Patent Claim Types:
see list of patent claims
Use; Composition;
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,639,738

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Canada2061566Feb 20, 1992

International Patent Family for Patent: 5,639,738

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Australia7022496Dec 19, 1996
European Patent Office0758246Feb 19, 1997
Denmark0445255Feb 18, 2002
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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