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Details for Patent: 5,639,443

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Summary for Patent: 5,639,443

Title: Stabilized microbubble compositions
Abstract:A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
Inventor(s): Schutt; Ernest G. (San Diego, CA), Evitts; David P. (La Jolla, CA), Kinner; Rene Alta (San Diego, CA), Anderson; Charles David (Lebanon, NJ), Weers; Jeffry G. (San Diego, CA)
Assignee: Alliance Pharmaceutical Corp. (San Diego, CA)
Application Number:08/405,447
Patent Claim Types:
see list of patent claims
Compound; Device; Delivery;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,639,443

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Norway973489Jul 30, 1997
South Korea100407755Feb 18, 2004
World Intellectual Property Organization (WIPO)9626746Sep 06, 1996
Spain2231775May 16, 2005
Hungary9802095Jan 28, 1999
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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