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Details for Patent: 5,633,352

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Summary for Patent: 5,633,352

Title: Biosynthetic human growth hormone
Abstract:A desired protein having the formula: wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extended protein having the formula: wherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.
Inventor(s): Dalb.o slashed.ge; Henrik (Virum, DK), Pedersen; John (Kokkedal, DK), Christensen; Thorkild (Aller.o slashed.d, DK), Ringsted; J.o slashed.rli W. (Br.o slashed.ndby, DK), Jessen; Torben E. (Holbaek, DK)
Assignee: Novo Nordisk A/S (DK)
Application Number:08/402,286
Patent Claim Types:
see list of patent claims
Compound;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Novo Nordisk Inc
NORDITROPIN
somatropin recombinant
INJECTABLE;INJECTION021148Jun 20, 2000DISCNNo5,633,352<disabled>
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Foreign Priority and PCT Information for Patent: 5,633,352

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Denmark5493/82Dec 10, 1982
Denmark556/85Feb 07, 1985

International Patent Family for Patent: 5,633,352

Country Document Number Publication Date
WIPO (PCT)8402351Jun 21, 1984
WIPO (PCT)8604609Aug 14, 1986
United States5618697Apr 08, 1997
United States5635604Jun 03, 1997
United States5679552Oct 21, 1997
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