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|Title:||Biosynthetic human growth hormone|
|Abstract:||A desired protein having the formula: wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extended protein having the formula: wherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.|
|Inventor(s):||Dalb.o slashed.ge; Henrik (Virum, DK), Pedersen; John (Kokkedal, DK), Christensen; Thorkild (Aller.o slashed.d, DK), Ringsted; J.o slashed.rli W. (Br.o slashed.ndby, DK), Jessen; Torben E. (Holbaek, DK)|
|Assignee:||Novo Nordisk A/S (DK)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|World Intellectual Property Organization (WIPO)||8402351||Jun 21, 1984|
|World Intellectual Property Organization (WIPO)||8604609||Aug 14, 1986|
|United States of America||5618697||Apr 08, 1997|
|United States of America||5635604||Jun 03, 1997|
|United States of America||5679552||Oct 21, 1997|
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