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Details for Patent: 5,616,582

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Summary for Patent: 5,616,582

Title: Quinazoline derivatives as anti-proliferative agents
Abstract:The invention concerns quinazoline derivatives of the formula I ##STR1## wherein m is 1, 2 or 3 and each R.sup.1 includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, hydroxyamino, (1-4C)alkoxyamino, (2-4C)alkanoyloxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; n is 1 or 2 and each R.sup.2 includes hydrogen, hydroxy, halogeno, trifluoromethyl, amino, nitro, cyano and (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
Inventor(s): Barker; Andrew J. (Macclesfield, GB2)
Assignee: Zeneca Limited (London, GB)
Application Number:08/490,666
Patent Claim Types:
see list of patent claims
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,616,582

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9201095Jan 20, 1992
United Kingdom9213572Jun 26, 1992
United Kingdom9223735Nov 12, 1992

International Patent Family for Patent: 5,616,582

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Japan2994165Dec 27, 1999
United Kingdom9213572Aug 12, 1992
Hungary221622Dec 28, 2002
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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