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Details for Patent: 5,616,334

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Patent 5,616,334 protects ABELCET and is included in one NDA.

Summary for Patent: 5,616,334

Title: Low toxicity drug-lipid systems
Abstract:Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Inventor(s): Janoff; Andrew S. (Yardley, PA), Boni; Lawrence (Monmouth Junction, NJ), Madden; Thomas D. (Vancouver, CA), Cullis; Pieter R. (Vancouver, CA), Lenk; Robert P. (Lambertville, NJ), Kearns; John J. (Princeton, NJ), Durning; Anthony G. (Yardley, PA), Klimchak; Robert (Flemington, NJ), Portnoff; Joel (Richboro, PA)
Assignee: The Liposome Company, Inc. (Princeton, NJ)
Application Number:08/430,699
Patent Claim Types:
see list of patent claims
Composition; Dosage form; Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Sigma Tau
ABELCET
amphotericin b
INJECTABLE, LIPID COMPLEX;INJECTION050724Nov 20, 1995RXYes5,616,334<disabled>Y
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International Patent Family for Patent: 5,616,334

Country Document Number Publication Date
South Africa8801477Aug 23, 1988
World Intellectual Property Organization (WIPO)8905636Jun 29, 1989
World Intellectual Property Organization (WIPO)8900846Feb 09, 1989
World Intellectual Property Organization (WIPO)8806443Sep 07, 1988
United States of America2002119170Aug 29, 2002
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