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|Title:||Low toxicity drug-lipid systems|
|Abstract:||Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.|
|Inventor(s):||Janoff; Andrew S. (Yardley, PA), Boni; Lawrence (Monmouth Junction, NJ), Madden; Thomas D. (Vancouver, CA), Cullis; Pieter R. (Vancouver, CA), Lenk; Robert P. (Lambertville, NJ), Kearns; John J. (Princeton, NJ), Durning; Anthony G. (Yardley, PA), Klimchak; Robert (Flemington, NJ), Portnoff; Joel (Richboro, PA)|
|Assignee:||The Liposome Company, Inc. (Princeton, NJ)|
Patent Claim Types:|
see list of patent claims
|Composition; Dosage form; Use;|
|Country||Document Number||Publication Date|
|Australia||622405||Apr 09, 1992|
|World Intellectual Property Organization (WIPO)||8905636||Jun 29, 1989|
|Australia||1799088||Sep 26, 1988|
|Spain||2070131||Jun 01, 1995|
|Canada||1330199||Jun 14, 1994|
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