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Details for Patent: 5,605,673

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Summary for Patent: 5,605,673

Title: Stabilized microbubble compositions for ultrasound
Abstract:A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at C., where x is the vapor pressure of the second gas at C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.
Inventor(s): Schutt; Ernest G. (San Diego, CA), Anderson; Charles D. (Lebanon, CA), Evitts; David P. (La Jolla, CA)
Assignee: Alliance Pharmaceutical Corp. (San Diego, CA)
Application Number:08/284,083
Patent Claim Types:
see list of patent claims
Use; Compound; Formulation; Delivery;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,605,673

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Hungary9802095Jan 28, 1999
European Patent Office0711179Sep 01, 2010
Norway973489Jul 30, 1997
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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