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|Title:||Stabilized microbubble compositions for ultrasound|
|Abstract:||A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.|
|Inventor(s):||Schutt; Ernest G. (San Diego, CA), Anderson; Charles D. (Lebanon, CA), Evitts; David P. (La Jolla, CA)|
|Assignee:||Alliance Pharmaceutical Corp. (San Diego, CA)|
Patent Claim Types:|
see list of patent claims
|Use; Compound; Formulation; Delivery;|
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Japan||4229918||Feb 25, 2009|
|European Patent Office||0812214||Dec 17, 1997|
|Australia||7478294||Feb 28, 1995|
|Australia||5199701||Aug 30, 2001|
|Norway||973489||Jul 30, 1997|
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