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Details for Patent: 5,587,497

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Patent 5,587,497 protects ZEMPLAR and is included in two NDAs. There have been three Paragraph IV challenges on Zemplar. There is one tentative approval for the compound protected by this patent. Additional details are available via the generic ingredient links below.

Protection for ZEMPLAR has been extended six months for pediatric studies, as indicated by the *PED designation in the table below.

Summary for Patent: 5,587,497

Title: 19-nor-vitamin D compounds
Abstract:This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided. The 19-nor vitamin D compounds have the formula: ##STR1## where X.sup.1 and X.sup.2 are each hydrogen or a hydroxy protecting group and R is a side chain.
Inventor(s): DeLuca; Hector F. (Deerfield, WI), Schnoes; Heinrich K. (Madison, WI), Perlman; Kato L. (Madison, WI), Sicinski; Rafal R. (Warsaw, PL), Prahl; Jean M. (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Application Number:08/442,492
Patent Claim Types:
see list of patent claims
Compound;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Abbvie
ZEMPLAR
paricalcitol
CAPSULE;ORAL021606May 26, 2005RXNo5,587,497*PED<disabled>Y
Abbvie
ZEMPLAR
paricalcitol
CAPSULE;ORAL021606May 26, 2005RXYes5,587,497*PED<disabled>Y
Abbvie
ZEMPLAR
paricalcitol
INJECTABLE;INJECTION020819Feb 1, 2000RXYes5,587,497*PED<disabled>Y
Abbvie
ZEMPLAR
paricalcitol
INJECTABLE;INJECTION020819Apr 17, 1998RXYes5,587,497*PED<disabled>Y
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International Patent Family for Patent: 5,587,497

Country Document Number Publication Date
South Africa9007119Oct 30, 1991
World Intellectual Property Organization (WIPO)9010620Sep 20, 1990
United States of America5237110Aug 17, 1993
United States of America5246925Sep 21, 1993
United States of America5321018Jun 14, 1994
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