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|Title:||19-nor-vitamin D compounds|
|Abstract:||This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided. The 19-nor vitamin D compounds have the formula: ##STR1## where X.sup.1 and X.sup.2 are each hydrogen or a hydroxy protecting group and R is a side chain.|
|Inventor(s):||DeLuca; Hector F. (Deerfield, WI), Schnoes; Heinrich K. (Madison, WI), Perlman; Kato L. (Madison, WI), Sicinski; Rafal R. (Warsaw, PL), Prahl; Jean M. (Madison, WI)|
|Assignee:||Wisconsin Alumni Research Foundation (Madison, WI)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|United States of America||5880113||Mar 09, 1999|
|United States of America||5710294||Jan 20, 1998|
|South Korea||950013636||Nov 13, 1995|
|United States of America||5633241||May 27, 1997|
|Japan||H0667899||Aug 31, 1994|
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