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Details for Patent: 5,585,397

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Patent 5,585,397 protects AGENERASE and is included in two NDAs.

Summary for Patent: 5,585,397

Title: Sulfonamide inhibitors of aspartyl protease
Abstract:The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
Inventor(s): Tung; Roger D. (Arlington, MA), Murcko; Mark A. (Holliston, MA), Bhisetti; Govinda R. (Lexington, MA)
Assignee: Vertex Pharmaceuticals, Incorporated (Cambridge, MA)
Application Number:08/142,327
Patent Claim Types:
see list of patent claims
Compound; Composition;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Glaxosmithkline
AGENERASE
amprenavir
CAPSULE;ORAL021007Apr 15, 1999DISCNNo5,585,397<disabled>
Glaxosmithkline
AGENERASE
amprenavir
SOLUTION;ORAL021039Apr 15, 1999DISCNNo5,585,397<disabled>
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Foreign Priority and PCT Information for Patent: 5,585,397

PCT Information
PCT FiledSeptember 07, 1993PCT Application Number:PCT/US93/08458
PCT Publication Date:March 17, 1994PCT Publication Number: WO94/05639

International Patent Family for Patent: 5,585,397

Country Document Number Publication Date
World Intellectual Property Organization (WIPO)9405639Mar 17, 1994
World Intellectual Property Organization (WIPO)9633184Oct 24, 1996
United States of America5723490Mar 03, 1998
United States of America5783701Jul 21, 1998
United States of America5856353Jan 05, 1999
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