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Details for Patent: 5,585,089

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Summary for Patent: 5,585,089

Title: Humanized immunoglobulins
Abstract:Novel methods for producing, and compositions of humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.
Inventor(s): Queen; Cary L. (Los Altos, CA), Selick; Harold E. (Belmont, CA)
Assignee: Protein Design Labs, Inc. (Mountain View, CA)
Application Number:08/477,728
Patent Claim Types:
see list of patent claims
Compound; Composition;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,585,089

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office0451216Jan 02, 199236/2007Austria<disabled>
European Patent Office0451216Jan 24, 1996SPC/GB09/055United Kingdom<disabled>
European Patent Office0451216Jun 13, 201242/2005Austria<disabled>
Netherlands300279Jul 02, 2007
European Patent Office0451216Jan 02, 1992C300239Netherlands<disabled>
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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