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Details for Patent: 5,543,150

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Summary for Patent: 5,543,150

Title: Method of progesterone delivery and affect thereof
Abstract:The present invention teaches that relatively low levels of serum progesterone, 1 to 6 ng/ml, may be used to prevent endometrial cancer. The vaginal delivery of progesterone using a cross-linked polycarboxylic polymer produces this low serum progesterone level while also providing the full secretory transformation of the endometrium, indicating the efficacy of the progesterone. Such low levels of serum progesterone will decrease the risk of breast cancer experienced by women undergoing hormone replacement therapy ("HRT") and minimize the potential of other undesirable progesterone associated side effects.
Inventor(s): Bologna; William J. (New York, NY), Levine; Howard L. (Oceanside, NY)
Assignee: Columbia Laboratories, Inc. (Coconut Grove, FL)
Application Number:08/122,371
Patent Claim Types:
see list of patent claims
Use; Delivery; Device;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,543,150

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Hungary9600669May 28, 1996
Peru50795Jan 19, 1996
Canada2171939Jan 01, 2002
Lithuania4072Nov 25, 1996
Norway308585Oct 02, 2000
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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