|Title:||Medical use for tachykinin antagonists|
|Abstract:||The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R.sup.1 is selected from halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, and S(O).sub.n C.sub.1-4 alkyl groups; R.sup.2 and R.sup.3, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl and cyano groups; n represents zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof.|
|Inventor(s):||Hagan; Russell M. (Ware, GB), Bunce; Keith T. (Ware, GB)|
|Assignee:||Glaxo Group Limited (London, GB2)|
Patent Claim Types:|
see list of patent claims
|Applicant||Tradename||Generic Name||Dosage||NDA||Approval Date||Type||RLD||Patent No.||Patent Expiration||Product||Substance||Delist Req.||Patented / Exclusive Use|
|CAPSULE;ORAL||021549||Jun 30, 2006||RX||No||5,538,982||<disabled>||TREATMENT OR PREVENTION OF EMESIS|
|CAPSULE;ORAL||021549||Mar 26, 2003||RX||No||5,538,982||<disabled>||TREATMENT OR PREVENTION OF EMESIS|
|CAPSULE;ORAL||021549||Mar 26, 2003||RX||Yes||5,538,982||<disabled>||TREATMENT OR PREVENTION OF EMESIS|
Merck And Co Inc
|POWDER;INTRAVENOUS||022023||Jan 25, 2008||DISCN||No||5,538,982||<disabled>||PREVENTION OR TREATMENT OF NAUSEA OR EMESIS INDUCED BY A CANCER CHEMOTHERAPEUTIC AGENT|
Merck And Co Inc
|POWDER;INTRAVENOUS||022023||Nov 12, 2010||RX||Yes||5,538,982||<disabled>||PREVENTION OR TREATMENT OF NAUSEA OR EMESIS INDUCED BY A CANCER CHEMOTHERAPEUTIC AGENT|
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