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Details for Patent: 5,532,415

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Summary for Patent: 5,532,415

Title: R-enantiomer of N-propargyl-1-aminoindan, salts, compositions and uses thereof
Abstract:The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.
Inventor(s): Youdim; Moussa B. H. (Haifa, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Berger-Paskin; Tirtsah (Raanana, IL), Yellin; Haim (Ramat-Gan, IL), Veinberg; Alex (Rehovot, IL)
Assignee: Teva Pharmaceutical Industries Ltd. (Jerusalem, IL) Technion Research and Development Foundation Ltd. (Haifa, IL)
Application Number:08/411,398
Patent Claim Types:
see list of patent claims
Compound;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Teva
AZILECT
rasagiline mesylate
TABLET;ORAL021641May 16, 2006RXNo5,532,415<disabled>Y
Teva
AZILECT
rasagiline mesylate
TABLET;ORAL021641May 16, 2006RXYes5,532,415<disabled>Y
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Foreign Priority and PCT Information for Patent: 5,532,415

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Israel92952Jan 03, 1990

International Patent Family for Patent: 5,532,415

Country Document Number Publication Date
South Africa9009997Oct 30, 1991
South Africa9408013May 31, 1995
World Intellectual Property Organization (WIPO)9511016Apr 27, 1995
World Intellectual Property Organization (WIPO)9637199Nov 28, 1996
United States of America2003065038Apr 03, 2003
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