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Details for Patent: 5,532,415

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Summary for Patent: 5,532,415

Title: R-enantiomer of N-propargyl-1-aminoindan, salts, compositions and uses thereof
Abstract:The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.
Inventor(s): Youdim; Moussa B. H. (Haifa, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Berger-Paskin; Tirtsah (Raanana, IL), Yellin; Haim (Ramat-Gan, IL), Veinberg; Alex (Rehovot, IL)
Assignee: Teva Pharmaceutical Industries Ltd. (Jerusalem, IL) Technion Research and Development Foundation Ltd. (Haifa, IL)
Application Number:08/411,398
Patent Claim Types:
see list of patent claims
Compound;
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,532,415

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Israel92952Jan 03, 1990

International Patent Family for Patent: 5,532,415

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office0436492Nov 13, 1991CA 2005 00040Denmark<disabled>
Canada2221458Nov 28, 1996
Hungary908051Jun 28, 1991
Israel118247Sep 12, 1996
Hungary9601012Jun 28, 1996
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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