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Details for Patent: 5,510,353

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Summary for Patent: 5,510,353

Title: Certain aminoguanidine compounds, pharmaceutical compositions containing them and their use in treating gastrointestinal motility disorders and disorders associated with cephalic pain
Abstract:Compounds of formula wherein A is derived from optionally substituted benzothiophene, indole, 4-aza-and 7-aza-benzothiophene or-indole, A bearing in position 5 hydrogen, halogen, optionally substituted alkyl, hydroxy, nitro, amino, alkylamino, acylamino, alkoxycarbonyl, sulfamoyl, cyano, trimethylsilyl, carboxy, carbamoyl, phosphate, oxycarbamoyl, heterocyclic radical or ether or ester group, X-Y is --CR.sub.8 .dbd.N-- or CH(R.sub.8)--NH-- wherein R.sub.8 is -H or alkyl and attached at position 3 of A, and B is a heterocyclic radical or a residue ##STR1## wherein R.sub.10 is H, optionally substituted alkyl, cycloalkyl, aryl, adamantyl, acyl or carbamoyl and X.sub.2 is alkylthio or NR.sub.3 R.sub.10 wherein R.sub.3 is H or alkyl or R.sub.3 and R.sub.10 together with the nitrogen atom to which they are attached form a heterocyclic radical, in free form or in salt form, have pharmacological activity, e.g. for treating gastrointestinal disorders.
Inventor(s): Giger; Rudolf K. A. (Muttenz, CH), Mattes; Henri (Brunstadt, FR)
Assignee: Sandoz Ltd. (Basel, CH)
Application Number:08/370,038
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,510,353

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9106179Mar 22, 1991
United Kingdom9107927Apr 15, 1991

International Patent Family for Patent: 5,510,353

Country Document Number Publication Date
South Africa9202071Sep 20, 1993
Slovak Republic279214Aug 05, 1998
Singapore43221Oct 17, 1997
Russia2095347Nov 10, 1997
Romania109194Dec 30, 1994
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