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Details for Patent: 5,468,755

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Summary for Patent: 5,468,755

Title: Therapeutic process for the treatment of the pathologies of Type II diabetes
Abstract:A process for the long term modification and regulation of lipid and carbohydrate metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes)--by administration (i.e., by oral, sublingual or parenternal administration) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of insulin resistant and insulin sensitive members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can be controlled in humans on a long term basis by such treatment inasmuch as the short term daily administration resets hormonal timing in the neural centers of the brain to produce long term effects.
Inventor(s): Cincotta; Anthony H. (Andover, MA), Meier; Albert H. (Baton Rouge, LA)
Assignee: The Board of Supervisors of Louisiana State University and Agricultural (Baton Rouge, LA)
Application Number:08/158,153
Patent Claim Types:
see list of patent claims
Use; Compound;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,468,755

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Australia702392Feb 18, 1999
South Africa9410263Aug 29, 1995
Spain2239316Sep 16, 2005
Canada2194501Jan 25, 1996
Hungary9700028Feb 28, 1997
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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