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Details for Patent: 5,446,194

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Summary for Patent: 5,446,194

Title: Pharmacologically active catechol derivatives
Abstract:A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.
Inventor(s): Backstrom; Reijo J. (Helsinki, FI), Heinola; Kalevi E. (Jarvempaa, FI), Honkanen; Erkki J. (Vantaa, FI), Kaakkola; Seppo K. (Helsinki, FI), Kairisalo; Pekka J. (Helsinki, FI), Linden; Inge-Britt Y. (Helsinki, FI), Mannisto; Pekka I. (Helsinki, FI), Nissinen; Erkki A. O. (Espoo, FI), Pohto; Pentti (Helsinki, FI), Pippuri; Aino K. (Espoo, FI), Pystynen; Jarmo J. (Espoo, FI)
Assignee: Orion-yhtyma Oy (Espoo, FI)
Application Number:08/121,617
Patent Claim Types:
see list of patent claims
Compound;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Orion Pharma
COMTAN
entacapone
TABLET;ORAL020796Oct 19, 1999RXYes5,446,194<disabled>Y
Orion Pharma
STALEVO 100
carbidopa; entacapone; levodopa
TABLET;ORAL021485Jun 11, 2003RXNo5,446,194<disabled>Y
Orion Pharma
STALEVO 125
carbidopa; entacapone; levodopa
TABLET;ORAL021485Aug 29, 2008RXNo5,446,194<disabled>Y
Orion Pharma
STALEVO 150
carbidopa; entacapone; levodopa
TABLET;ORAL021485Jun 11, 2003RXNo5,446,194<disabled>Y
Orion Pharma
STALEVO 200
carbidopa; entacapone; levodopa
TABLET;ORAL021485Aug 2, 2007RXYes5,446,194<disabled>Y
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Foreign Priority and PCT Information for Patent: 5,446,194

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Finland864875Nov 28, 1986
United Kingdom8712437May 27, 1987

International Patent Family for Patent: 5,446,194

Country Document Number Publication Date
Argentina243491Aug 31, 1993
Austria401053Jun 25, 1996
AustriaA312987Oct 15, 1995
Austria148626Feb 15, 1997
Australia8187987Jun 02, 1988
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