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Details for Patent: 5,424,078

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Summary for Patent: 5,424,078

Title: Aqueous ophthalmic formulations and methods for preserving same
Abstract:Stabilized chlorine dioxide is a preservative for ophthalmic formulations. The stabilized chlorine dioxide, when employed as a preservative ophthalmic formulations is preferably present in an amount of from about 0.0002 or about 0.002 to about 0.02 weight/volume percent. The aqueous ophthalmic formulations, in addition to the stabilized chlorine dioxide and the water which functions as a vehicle for the formulations, contains an ophthalmically acceptable tonicity component effective to maintain the osmolality of the formulation at least about 200 mOsmol/kg, and a buffer to maintain the pH of the ophthalmic formulation within an acceptable physiological range. A method for preserving aqueous ophthalmic formulations utilizing stabilized chlorine dioxide is also set forth.
Inventor(s): Dziabo; Anthony J. (El Toro, CA), Ripley; Paul S. (Irvine, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:07/694,640
Patent Claim Types:
see list of patent claims
Use; Formulation;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,424,078

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Ireland81090Mar 08, 2000
China1055874Nov 06, 1991
South Korea0160443Dec 01, 1998
Portugal92453Jul 18, 1995
Norway894740Nov 28, 1989
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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