|Title:||Aqueous ophthalmic formulations and methods for preserving same|
|Abstract:||Stabilized chlorine dioxide is a preservative for ophthalmic formulations. The stabilized chlorine dioxide, when employed as a preservative ophthalmic formulations is preferably present in an amount of from about 0.0002 or about 0.002 to about 0.02 weight/volume percent. The aqueous ophthalmic formulations, in addition to the stabilized chlorine dioxide and the water which functions as a vehicle for the formulations, contains an ophthalmically acceptable tonicity component effective to maintain the osmolality of the formulation at least about 200 mOsmol/kg, and a buffer to maintain the pH of the ophthalmic formulation within an acceptable physiological range. A method for preserving aqueous ophthalmic formulations utilizing stabilized chlorine dioxide is also set forth.|
|Inventor(s):||Dziabo; Anthony J. (El Toro, CA), Ripley; Paul S. (Irvine, CA)|
|Assignee:||Allergan, Inc. (Irvine, CA)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Spain||2098226||May 01, 1997|
|Japan||H02184631||Jul 19, 1990|
|European Patent Office||0371728||Jan 08, 1997|
|Hungary||206455||Nov 30, 1992|
|Hungary||896225||Feb 28, 1990|
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