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|Title:||Methods of inhibiting transplant rejecton in mammals using rapamycin and derivatives and prodrugs thereof|
|Abstract:||This invention provides a method of inhibiting organ or tissue transplant rejection in a mammal in need thereof, comprising administering to said mammal a transplant rejection inhibiting amount of rapamycin. Also disclosed is a method of inhibiting organ or tissue transplant rejection in a mammal in need thereof, comprising administering to said mammal (a) an amount of rapamycin in combination with (b) an amount of one or more other chemotherapeutic agents for inhibiting transplant rejection, e.g., azathioprine, corticosteroids, cyclosporin and FK506, said amounts of (a) and (b) together being effective to inhibit transplant rejection and to maintain inhibition of transplant rejection.|
|Inventor(s):||Calne; Sir Roy (Cambridge, GB2)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|United States of America||5100899||Mar 31, 1992|
|United States of America||5212155||May 18, 1993|
|United States of America||5308847||May 03, 1994|
|United States of America||5461058||Oct 24, 1995|
|Singapore||44632||Dec 19, 1997|
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