Patent 4,939,130 protects and is included in zero NDA.
|Title:||Substituted alkanediphosphonic acids and pharmaceutical use|
|Abstract:||Alkanediphosphonic acids, in particular heteroarylalkanediphosphonic acids of formula ##STR1## wherein R.sub.1 is a 5-membered heteroaryl radical which may be fused with benzene or cyclohexene nuclei and which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy and/or halogen, or by lower alkoxy, hydroxy, di-lower alkylamino, lower alkylthio and/or halogen, and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen, and R.sub.2 is hydrogen, hydroxy, amino, lower alkylthio or halogen, and salts thereof, have regulatory action on calcium metabolism and can be used as medicaments for the treatment of diseases associated with impairment of calcium metabolism. The compounds are obtained for example by converting, in a compound of formula ##STR2## wherein X.sub.1 is a functionally modified phosphono group and X.sub.2 is a free or functionally modified phosphono group, X.sub.1 and, if appropriate X.sub.2, into the free phosphono group.|
|Inventor(s):||Jaeggi; Knut A. (Basel, CH), Widler; Leo (Muchenstein, CH)|
|Assignee:||Ciba-Geigy Corporation (Ardsley, NY)|
Patent Claim Types:|
see list of patent claims
|Compound; Use; Composition; Compound; Composition; Use;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|Switzerland||4666/86||Nov 21, 1986|
|Country||Document Number||Publication Date|
|South Africa||8708698||May 23, 1988|
|Singapore||92194||Apr 28, 1995|
|Portugal||86167||Dec 01, 1987|
|Philippines||24345||Jun 13, 1990|
|New Zealand||222610||Sep 26, 1990|
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