Details for Patent: 8,268,299
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Which drugs does patent 8,268,299 protect, and when does it expire?
Patent 8,268,299 protects TRAVATAN Z and is included in one NDA.
This patent has twenty-nine patent family members in twenty-three countries.
Summary for Patent: 8,268,299
Title: | Self preserved aqueous pharmaceutical compositions |
Abstract: | The present invention is directed to the provision of multi-dose, self-preserved ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP), without requiring the presence of conventional anti-microbial preservative agents, such as benzalkonium chloride. The compositions are effectively preserved by a balanced ionic buffer system containing zinc ions at a concentration of 0.04 to 0.9 mM, preferably 0.04 to 0.4 mM. One aspect of the balanced buffer system is limitation of the amount of buffering anions present to a concentration of 15 mM or less, preferably 5 mM or less. In a preferred embodiment, the compositions also contain borat or, most preferably, one or more borate/polyol complexes. The use of propylene glycol as the polyol in such complexes is strongly preferred. Limiting the amount of divalent metals other than zinc and the amount of ionized salts present has also been determined to be important to maximize the antimicrobial activity of the balanced buffer systems. |
Inventor(s): | Kabra; Bhagwati P. (Euless, TX), Chowhan; Masood A. (Arlington, TX), Schneider; L. Wayne (Crowley, TX), Han; Wesley Wehsin (Arlington, TX) |
Assignee: | Alcon Research, Ltd. (Fort Worth, TX) |
Application Number: | 11/858,781 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 8,268,299 |
Patent Claim Types: see list of patent claims | Composition; |
Drugs Protected by US Patent 8,268,299
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sandoz | TRAVATAN Z | travoprost | SOLUTION/DROPS;OPHTHALMIC | 021994-001 | Sep 21, 2006 | AT | RX | Yes | Yes | ⤷ Try a Trial | ⤷ Try a Trial | Y | ⤷ Try a Trial | |||
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 8,268,299
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
Argentina | 062929 | ⤷ Try a Trial | |||
Austria | E531358 | ⤷ Try a Trial | |||
Australia | 2007299727 | ⤷ Try a Trial | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |