Details for Patent: 5,886,184
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Summary for Patent: 5,886,184
Title: | Finasteride processes |
Abstract: | Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production. |
Inventor(s): | Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ) |
Assignee: | Merck & Co., Inc. (Rahway, NJ) |
Application Number: | 08/824,426 |
Patent Claim Types: see list of patent claims | Compound; Process; |
Drugs Protected by US Patent 5,886,184
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