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Last Updated: March 28, 2024

Details for Patent: 5,703,110


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Summary for Patent: 5,703,110
Title: Benzimidazole derivatives, their production and use
Abstract:Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m -- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
Inventor(s): Naka; Takehiko (Kobe, JP), Nishikawa; Kohei (Kyoto, JP), Kato; Takeshi (Higashiosaka, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/715,100
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,703,110

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,703,110

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan2-113148Apr 27, 1990
Japan2-141942May 30, 1990
Japan2-208662Aug 06, 1990
Japan2-264579Oct 01, 1990
Japan2-413679Dec 24, 1990

International Family Members for US Patent 5,703,110

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 146779 ⤷  Try a Trial
Austria 227709 ⤷  Try a Trial
Australia 647469 ⤷  Try a Trial
Australia 7533191 ⤷  Try a Trial
Brazil 1100710 ⤷  Try a Trial
Canada 2040955 ⤷  Try a Trial
Canada 2204290 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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