Details for Patent: 5,135,950
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Summary for Patent: 5,135,950
| Title: | Stable polymorphic form of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation |
| Abstract: | Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT). |
| Inventor(s): | Pippuri; Aino K. (Espoo, FI), Honkanen; Erkki J. (Vantaa, FI), Haarala; Jorma V. (Helsinki, FI) |
| Assignee: | Orion-yhtyma Oy (Espoo, FI) |
| Application Number: | 07/606,717 |
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Patent Claim Types: see list of patent claims | Compound; Process; Use; Composition; |
Drugs Protected by US Patent 5,135,950
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 5,135,950
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| United Kingdom | 8924838.9 | Nov 03, 1989 |
International Family Members for US Patent 5,135,950
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Austria | 127447 | ⤷ Try a Trial | |||
| Brazil | 1100289 | ⤷ Try a Trial | |||
| Germany | 122004000014 | ⤷ Try a Trial | |||
| Germany | 69022166 | ⤷ Try a Trial | |||
| Denmark | 0426468 | ⤷ Try a Trial | |||
| European Patent Office | 0426468 | ⤷ Try a Trial | 91071 | Luxembourg | ⤷ Try a Trial |
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
