Details for Patent: 4,939,130
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Summary for Patent: 4,939,130
Title: | Substituted alkanediphosphonic acids and pharmaceutical use |
Abstract: | Alkanediphosphonic acids, in particular heteroarylalkanediphosphonic acids of formula ##STR1## wherein R.sub.1 is a 5-membered heteroaryl radical which may be fused with benzene or cyclohexene nuclei and which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy and/or halogen, or by lower alkoxy, hydroxy, di-lower alkylamino, lower alkylthio and/or halogen, and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen, and R.sub.2 is hydrogen, hydroxy, amino, lower alkylthio or halogen, and salts thereof, have regulatory action on calcium metabolism and can be used as medicaments for the treatment of diseases associated with impairment of calcium metabolism. The compounds are obtained for example by converting, in a compound of formula ##STR2## wherein X.sub.1 is a functionally modified phosphono group and X.sub.2 is a free or functionally modified phosphono group, X.sub.1 and, if appropriate X.sub.2, into the free phosphono group. |
Inventor(s): | Jaeggi; Knut A. (Basel, CH), Widler; Leo (Muchenstein, CH) |
Assignee: | Ciba-Geigy Corporation (Ardsley, NY) |
Application Number: | 07/315,962 |
Patent Claim Types: see list of patent claims | Compound; Use; Composition; |
Drugs Protected by US Patent 4,939,130
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 4,939,130
Foriegn Application Priority Data | ||
Foreign Country | Foreign Patent Number | Foreign Patent Date |
Switzerland | 4666/86 | Nov 21, 1986 |
International Family Members for US Patent 4,939,130
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Austria | 72816 | ⤷ Try a Trial | |||
Australia | 607722 | ⤷ Try a Trial | |||
Australia | 8145387 | ⤷ Try a Trial | |||
Canada | 1338937 | ⤷ Try a Trial | |||
Cyprus | 1827 | ⤷ Try a Trial | |||
German Democratic Republic | 270533 | ⤷ Try a Trial | |||
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