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Last Updated: March 28, 2024

Details for Patent: 7,666,881


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Title:Methods of treating allergic reactions using hydrated forms of antihistaminic piperidine derivatives
Abstract: The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas ##STR00001## which are useful as antihistamines, antiallergic agents and bronchodilators.
Inventor(s): Henton; Daniel R. (Midland, MI), McCarty; Frederick J. (Cincinnati, OH), Tripp; Susan I. (Lee's Summit, MO), DeWitt; Jill E. (Kansas City, MO)
Assignee: Aventis Holdings, Inc. (Bridgewater, NJ)
Filing Date:Sep 25, 2006
Application Number:11/534,828
Claims:1. A method of treating an allergic reaction in a patient in need thereof comprising administering to said patient a solid unit dosage form comprising an effective amount of 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.a- lpha.-dimethylbenzeneacetic acid hydrochloride comprising Form II hydrated 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.a- lpha.-dimethylbenzeneacetic acid hydrochloride.

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