Details for Patent: 7,344,705
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| Title: | Composition comprising low density microspheres |
| Abstract: | Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons. |
| Inventor(s): | Unger; Evan C. (Tucson, AZ) |
| Assignee: | Bristol-Myers Squibb Medical Imaging, Inc. (Princeton, NJ) |
| Filing Date: | Oct 18, 2005 |
| Application Number: | 11/252,659 |
| Claims: | 1. A composition comprising low density microspheres, said microspheres comprising a polymer and having a void containing the vapor of a volatile liquid perfluorocarbon, wherein said microspheres, when combined with an aqueous solution to form a contrast agent, are suitable for administration to a patient either orally, rectally or by injection, and further wherein said microspheres have an internal void volume which is at least about 75% of the total volume of said microspheres. 2. The composition of claim 1, wherein said microspheres have a void volume of at least about 80% of the total volume of said microspheres. 3. The composition of claim 1, wherein said microspheres have a void volume of at least about 85% of the total volume of said microspheres. 4. The composition of claim 1, wherein said microspheres have a void volume of at least about 90% of the total volume of said microspheres. |
