Details for Patent: 6,762,290
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Title: | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
Abstract: | Methods are described for the identification and preparation of high-affinity nucleic acid ligands to a VEGF receptor. Included in the invention are specific RNA ligands to a VEGF receptor identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of a VEGF receptor with VEGF. |
Inventor(s): | Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO) |
Assignee: | Gilead Sciences, Inc. (Foster City, CA) |
Filing Date: | Jul 29, 1999 |
Application Number: | 09/364,540 |
Claims: | 1. A purified and isolated non-naturally occurring RNA nucleic acid ligand to VEGFR2 wherein said ligand is selected from the group consisting of the sequences set forth in SEQ ID NO:2 to SEQ ID NO:36. |