Details for Patent: 6,638,930
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| Title: | Morpholine and thiomorpholine tachykinin receptor antagonists |
| Abstract: | Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia. |
| Inventor(s): | Dorn; Conrad P. (Plainfield, NJ), Finke; Paul E. (Milltown, NJ), Hale; Jeffrey J. (Westfield, NJ), Maccoss; Malcolm (Freehold, NJ), Mills; Sander G. (Woodbridge, NJ), Shah; Shrenik K. (Metuchen, NJ), Chambers; Mark Stuart (Watford, GB), Harrison; Timothy (Great Dunmow, GB), Ladduwahetty; Tamara (Buckhurst Hill, GB), Williams; Brian John (Great Dunnow, GB) |
| Assignee: | Merck & Co. Inc. (Rahway, NJ) |
| Filing Date: | Apr 17, 2001 |
| Application Number: | 09/836,716 |
| Claims: | 1. A method for the treatment of bladder detrusor hyperreflexia in a mammal in need thereof which comprises administering to the mammal an effective amount of a compound which is: ##STR28## or a pharmaceutically acceptable salt thereof. 2. The method of claim 1 wherein the mammal is a human. 3. A method for the prevention of bladder detrusor hyperreflexia in a mammal in need thereof which comprises administering to the mammal an effective amount of a compound which is: ##STR29## or a pharmaceutically acceptable salt thereof. 4. The method of claim 3 wherein the mammal is a human. |
