Details for Patent: 6,531,610
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Title: | Retroviral protease inhibiting compounds |
Abstract: | A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed. |
Inventor(s): | Kempf; Dale J. (Libertyville, IL), Norbeck; Daniel W. (Crystal Lake, IL) |
Assignee: | Abbott Laboratories (Abbott Park, IL) |
Filing Date: | Jul 20, 2000 |
Application Number: | 09/619,785 |
Claims: | 1. An acylating compound of the formula: ##STR18## wherein R.sub.6 is hydrogen or loweralkyl; R.sub.7 is thiazolyl, oxazolyl, isoxazolyl or isothiazolyl wherein the thiazolyl, oxazolyl, isoxazolyl or isothiazolyl ring is unsubstituted or substituted with loweralkyl; and L is an activating group for an acylation reaction, with the proviso that when R.sub.6 is hydrogen and R.sub.7 is 5-thiazolyl, L is other than p-nitrophenyl. 2. The compound of claim 1 wherein R.sub.6 is hydrogen and R.sub.7 is thiazolyl, oxazolyl, isoxazolyl or isothiazolyl. 3. The compound of claim 1 wherein R.sub.6 is hydrogen and R.sub.7 is 5-thiazolyl, 5-oxazolyl, 5-isoxazolyl or 5-isothiazolyl. 4. The compound of claim 1 wherein L is p-nitrophenyl, phenyl, N-succinimidyl, N-phthalimidyl, N-benzotriazolyl, N-5-norbornene-2,3-carboxamidyl or 2,4,5-trichlorophenyl. 5. An acylating compound of the formula: ##STR19## wherein L is an activating group for an acylation reaction, with the proviso that L is other than p-nitrophenyl. 6. The compound of claim 5 wherein L is phenyl, N-succinimidyl, N-phthalimidyl, N-benzotriazolyl, N-5-norbornene-2,3-carboxamidyl or 2,4,5-trichlorophenyl. 7. The compound of claim 5 wherein L is phenyl. 8. The compound of claim 5 wherein L is N-succinimidyl. 9. The compound of claim 5 wherein L is N-phthalimidyl. 10. The compound of claim 5 wherein L is N-benzotriazolyl. 11. The compound of claim 5 wherein L is N-5-norbornene-2,3-carboxamidyl. 12. The compound of claim 5 wherein L is 2,4,5-trichiorophenyl. |