Details for Patent: 6,022,520
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| Title: | Radiolabeled compounds for thrombus imaging |
| Abstract: | This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body. |
| Inventor(s): | Dean; Richard T. (Bedford, NH), Lister-James; John (Bedford, NH) |
| Assignee: | Diatide, Inc. (Londonderry, NH) |
| Filing Date: | Jun 19, 1998 |
| Application Number: | 09/100,536 |
| Claims: | 1. A method of imaging a thrombus within a mammalian body comprising the steps of: a) administering an effective diagnostic amount of a radiolabeled reagent comprising i) a radiolabel complexing moiety; and ii) a platelet glycoprotein IIb/IIIa-binding compound covalently linked to the moiety and having a molecular weight less than 10,000 daltons; wherein said reagent is capable of inhibiting human platelet aggregation in platelet-rich plasma by 50% when present at a concentration not greater than about 1 .mu.M; and b) detecting a radiolabel localized at said thrombus. 2. The method of claim 1, wherein the radiolabel is selected from the group consisting of technetium-99m, indium-111, and gallium-68. 3. The method of claim 2, wherein the radiolabel is technetium-99m. 4. The method of claim 3, wherein the reagent is CH.sub.2 CO--Y.sub.D ApcGDCGGC.sub.Acm GC.sub.Acm GGC.amide. |
