Details for Patent: 5,807,537
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| Title: | Technetium-99m labeled peptides for imaging comprising a single thiol moiety |
| Abstract: | The invention elates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body. |
| Inventor(s): | Dean; Richard T. (Bedford, NH), McBride; William (Manchester, NH), Buttram; Scott (Derry, NH) |
| Assignee: | Diatide, Inc. (Londonderry, NH) |
| Filing Date: | Jun 05, 1995 |
| Application Number: | 08/462,212 |
| Claims: | 1. A compound comprising: a) a peptide having between 4 and 100 amino acid residues; and b) covalently linked to the peptide, a radioisotope complexing group comprising a single reduced thiol moiety that is: wherein A is H or HOOC; B is H, SH, or NHR", where R" is H or lower alkyl; X is SH or NHR", where R" is H or lower alkyl; R and R' are independently H or lower alkyl; n is 0, 1 or 2; and where B is NHR", X is SH and n is 1 or 2; where X is NHR", B is SH and n is 1 or 2; where B is H, A is HOOC, X is SH and n is 0 or 1; wherein the compound is capable of imaging target sites within a mammalian body when labeled with technetium-99m. 2. The compound according to claim 1 wherein the peptide and the complexing group are covalently linked through one or more amino acids. 3. The compound according to claim 1 wherein the peptide is chemically synthesized in vitro. 4. The compound according to claim 3 wherein the peptide is synthesized by solid phase peptide synthesis. 5. The compound according to claim 3 wherein the complexing group is covalently linked to the peptide during in vitro chemical synthesis. 6. The compound according to claim 4 wherein the completing group is covalently linked to the peptide during solid phase peptide synthesis. |
