Details for Patent: 5,674,882
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| Title: | Retroviral protease inhibiting compounds |
| Abstract: | A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed. |
| Inventor(s): | Kempf; Dale J. (Libertyville, IL), Norbeck; Daniel W. (Crystal Lake, IL), Sham; Hing Leung (Gurnee, IL), Zhao; Chen (Gurnee, IL) |
| Assignee: | Abbott Laboratories (Abbott Park, IL) |
| Filing Date: | Mar 29, 1995 |
| Application Number: | 08/413,136 |
| Claims: | 1. A method for inhibiting an HIV infection comprising administering to a human in need thereof a therapeutically effective amount of (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)-amino)ca rbonyl)valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-dipheny l-3-hydroxyhexane or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of another HIV protease inhibiting compound. 2. The method of claim 1 wherein the other HIV inhibiting is selected from the group of Ro 31-8959 SC-52151 KNI-227 and KNI-272. 3. A method for inhibiting an HIV infection comprising administering to a human in need thereof a therapeutically effective amount of (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)-amino)ca rbonyl)valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-dipheny l-3-hydroxyhexane or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of Ro 31-8959. |
