You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 6,143,771


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 6,143,771
Title: Compounds
Abstract:The novel optically pure compounds Na.sup.+, Mg.sup.2+, Li.sup.+, K.sup.+, Ca.sup.2+ and N.sup.+ (R).sub.4 salts of (+)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H- benzimidazole or (-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H- benzimidazole, in particular sodium and magnesium salt form thereof, where R is an alkyl with 1-4 carbon atoms, processes for the preparation thereof and pharmaceutical preparations containing the compounds as active ingredients, as well as the use of the compounds in pharmaceutical preparations and intermediates obtained by preparing the compounds.
Inventor(s): Lindberg; Per Lennart (Molndal, SE), von Unge; Sverker (Fjar.ang.s, SE)
Assignee: AstraZeneca AB (Sodertalje, SE)
Application Number:09/419,456
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,143,771
Patent Claims: 1. A pharmaceutical formulation for parenteral administration comprising an optically pure solid state Na.sup.+ salt of the (-)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzi midazole as active ingredient, and a pharmaceutically acceptable carrier.

2. A pharmaceutical formulation for parenteral administration comprising an injection solution comprising an optically pure solid state Na.sup.+ salt of the (-)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzi midazole as active ingredient, and a pharmaceutically acceptable carrier in the form of a pharmaceutically acceptable solvent having a volume sufficient to effect a solution having a concentration of 0.1 to 10% by weight of the active ingredient.

3. The pharmaceutical formulation according to claim 1 or 2, wherein the solid state salt is in substantially crystalline form.

4. The pharmaceutical formulation according to claim 1 or 2, further comprising a stabilizing agent, a buffering agent or a mixture thereof.

5. The pharmaceutical formulation for parenteral administration according to claim 1, comprising an injectable solution.

6. A method of inhibiting gastric acid secretion comprising the parenteral administration to a mammal including man in need of such treatment of a pharmaceutical formulation comprising a therapeutically effective amount of an optically pure solid state Na.sup.+ salt of the (-)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzi midazole and a pharmaceutically acceptable carrier.

7. A method for the treatment of gastrointestinal inflammatory disease comprising the parenteral administration to a mammal including man in need of such treatment of a pharmaceutical formulation comprising a therapeutically effective amount of an optically pure solid state Na.sup.+ salt of the (-)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzi midazole, and a pharmaceutically acceptable carrier.

8. The method according to claim 7, wherein a solution with the solvent carrier is prepared immediately before the administration.

9. The method according to claim 6 or 7, wherein the pharmaceutically acceptable carrier is in the form of a solvent.

10. The method of claim 7, wherein the solvent has a volume effecting a solution of a concentration of 0.1-10% by weight of the active ingredient.

11. A method of inhibiting gastric acid secretion comprising injecting a mammal including man in need of such treatment with a solution of an optically pure solid state Na.sup.+ salt of the (-)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzi midazole and a pharmaceutically acceptable solvent having a volume sufficient to effect a solution having a concentration of 0.1 to 10% by weight of the active ingredient.

12. A method for the treatment of gastrointestinal inflammatory disease comprising injecting a mammal including man in need of such treatment with a solution of an optically pure solid state Na.sup.+ salt of the (-)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzi midazole and a pharmaceutically acceptable solvent having a volume sufficient to effect a solution having a concentration of 0.1 to 10% by weight of the active ingredient.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.