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Details for Generic Name: perflutren

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Perflutren is the generic ingredient in one branded drug marketed by Lantheus Medcl and is included in one NDA. There are four patents protecting this compound. Additional information is available in the individual branded drug profile pages.

This ingredient has one hundred and eight patent family members in thirty countries.

One supplier is listed for this compound.

Summary for Generic Name: perflutren

Tradenames:1
Patents:4
Applicants:1
NDAs:1
Drug Master File Entries: 0
Suppliers: see list1
Formulation / Manufacturing:see details

Pharmacology for Ingredient: perflutren

Clinical Trials for: perflutren

A Prospective, Phase IV, Surveillance Registry Study to Evaluate the Safety of DEFINITY® in Clinical Practice
Status: Completed Condition: Cardiovascular Disease

Evaluation of Intra-operative Ultrasound Contrast Enhancement in the Evaluation of Liver Tumors
Status: Terminated Condition: Liver Tumors

A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure
Status: Completed Condition: Pulmonary Heart Disease

3-D Transcranial Ultrasound Analysis Study
Status: Completed Condition: Cerebrovascular Accident; Intracranial Hypertension

Feasibility of Ultrasound Microbubble Contrast-Enhanced (CEUS) Sentinel Lymph Node Imaging With Guided Biopsy in Breast Cancer Patients
Status: Not yet recruiting Condition: Breast Cancer

Breast VCEUS to Evaluate Early Response to Neoadjuvant Chemotherapy
Status: Not yet recruiting Condition: Breast Cancer

Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy
Status: Recruiting Condition: Breast Cancer

Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular Age-related Macular Degeneration
Status: Recruiting Condition: Exudative Macular Degeneration; Retinal Hemorrhage

Estimation of Pulmonary Vascular Resistance by Contrast Echocardiography
Status: Completed Condition: Pulmonary Arterial Hypertension

MRI / Ultrasound Fusion With Contrast-Enhanced Ultrasound Guidance
Status: Active, not recruiting Condition: Prostatic Neoplasms

Courtesy of ClinicalTrials.org
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Lantheus Medcl
DEFINITY
perflutren
INJECTABLE;INTRAVENOUS021064-001Jul 31, 2001RXYes8,685,441<disabled><disabled>
Lantheus Medcl
DEFINITY
perflutren
INJECTABLE;INTRAVENOUS021064-001Jul 31, 2001RXYes5,527,521<disabled>Y<disabled>
Lantheus Medcl
DEFINITY
perflutren
INJECTABLE;INTRAVENOUS021064-001Jul 31, 2001RXYes8,658,205<disabled>Y<disabled>
Lantheus Medcl
DEFINITY
perflutren
INJECTABLE;INTRAVENOUS021064-001Jul 31, 2001RXYes6,033,645<disabled><disabled>
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Non-Orange Book Patents for Generic Ingredient: perflutren

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,998,107Composition comprising low density microspheres<disabled in preview>
5,456,900 Low density microspheres and their use as contrast agents for computed tomography<disabled in preview>
5,205,290 Low density microspheres and their use as contrast agents for computed tomography<disabled in preview>
6,773,696 Contrast agent comprising low density microspheres<disabled in preview>
8,747,892Preparation of a lipid blend and a phospholipid suspension containing the lipid blend<disabled in preview>
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International Patent Family for Ingredient: perflutren

Country Document Number Publication Date
European Patent Office0930844Jul 28, 1999
European Patent Office1064953Jan 03, 2001
JapanH10500691Jan 20, 1998
European Patent Office0804932Nov 05, 1997
European Patent Office1027035Aug 16, 2000
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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