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Details for Generic Name: epinephrine; lidocaine hydrochloride

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Epinephrine; lidocaine hydrochloride is the generic ingredient in nine branded drugs marketed by Carlisle, Eastman Kodak, Graham Chem, Hikma Maple , Hospira, Abbott, Bel Mar, Dell Labs, Intl Medication, Watson Labs, Pharmaton, Septodont, Dentsply Pharm, Astrazeneca, Fresenius Kabi Usa, Vyteris, Iomed, and Empi, and is included in thirty-one NDAs. There are seven patents protecting this compound. Additional information is available in the individual branded drug profile pages.

There are twelve drug master file entries for epinephrine; lidocaine hydrochloride. Six suppliers are listed for this compound.

Summary for Generic Name: epinephrine; lidocaine hydrochloride

Drug Master File Entries: see list12
Suppliers: see list6

Pharmacology for Ingredient: epinephrine; lidocaine hydrochloride

Clinical Trials for: epinephrine; lidocaine hydrochloride

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine
Status: Recruiting Condition: Pain, Postoperative

Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery
Status: Recruiting Condition: Carpal Tunnel Syndrome

Gluing Lacerations Utilizing Epinephrine
Status: Completed Condition: Lacerations

Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Nasal Sephoplasty Surgery.
Status: Completed Condition: Surgery; Pain

Anesthesia With Epinephrine in Diabetes Patients is Safe and Effective
Status: Completed Condition: Type 2 Diabetes Mellitus; Coronary Disease

Comparison of Epinephrine-lidocaine Solution and Dexmedetomidine -Lidocaine Solution
Status: Completed Condition: Craniotomy

Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits
Status: Completed Condition: Irreversible Pulpitis; Pain

Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in Healthy Adult Volunteers
Status: Completed Condition: Local Anesthesia

The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Status: Completed Condition: Pain

Tumescent Lidocaine Maximum Safe mg/kg Dosage
Status: Enrolling by invitation Condition: Anesthesia

Effect of Sufentanil on the Rate of Anesthesia
Status: Completed Condition: Irreversible Pulpitis

Effectiveness Study of Different Local Anesthetic Mixtures
Status: Completed Condition: Pain

Effect of Fentanyl on the Rate of Anesthesia
Status: Completed Condition: Painful Irreversible Pulpitis

Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia
Status: Completed Condition: Anesthesia

Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease
Status: Completed Condition: Rheumatic Heart Disease; Pregnancy; Dental Caries

Efficacy of Buffered Lidocaine in Patients With Facial Swelling
Status: Completed Condition: Facial Swelling

Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning
Status: Recruiting Condition: Pain and Discomfort During Scaling and Root Planning of Patients With; Periodontitis

Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis
Status: Completed Condition: Local Anesthesia

Saline Injection - Assisted Anesthesia in Eyelid Surgery
Status: Recruiting Condition: Blepharoptosis

A Comparison of Tumescence in Breast Reduction Surgery
Status: Recruiting Condition: Pain, Postoperative; Postoperative Nausea and Vomiting

The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Status: Not yet recruiting Condition: Chronic Sinusitis

Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
Status: Completed Condition: Acute Otitis Media; Chronic Otitis Media; Recurrent Acute Otitis Media

Three-level Injection Paravertebral Block vs General Anesthesia in Mastectomy
Status: Completed Condition: Radical Mastectomy

Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)
Status: Completed Condition: Uterine Cervical Dysplasia

Use of Recombinant Hyaluronidase Human is Effective for the Use of Local Blocks for Eyelid's Surgery
Status: Withdrawn Condition: Upper Eyelid Surgery

The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.
Status: Recruiting Condition: Epistaxis; Blood Pressure

Dental Anesthesia in Heart Failure Patients
Status: Not yet recruiting Condition: Heart Failure

Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
Status: Completed Condition: Syncope, Vasovagal; Pain Intensity

The Efficacy of Analgesic Buffering With Sodium Bicarbonate for the Pediatric Dental Patient
Status: Recruiting Condition: Pediatric Dentistry

The Simultaneous Use of Supraclavicular and Distal Blocks
Status: Completed Condition: Orthopaedic Disorders; Nerve Block; Anaesthesia

Anesthesia for Dental Treatment in Cardiac Patients: Lidocaine Comparative Study
Status: Completed Condition: Arrhythmias; Anxiety

Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
Status: Completed Condition: Methemoglobinemia

Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine
Status: Completed Condition: Open Reduction Internal Fixation(ORIF) of Lateral Malleolus

Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Status: Completed Condition: Anesthetic Effectiveness

Does Intraperitoneal Instillation of Lidocaine at Cesarean Delivery Improve Postoperative Analgesia?
Status: Recruiting Condition: Pain

Shamrock Versus Lumbar Ultrasound Trident - Ultrasound Guided Block of the Lumbar Plexus
Status: Not yet recruiting Condition: Hip Fractures; Anesthesia Local; Pain, Postoperative

Reducing Side-effects of Autologous Skin Tissue Harvesting
Status: Not yet recruiting Condition: Scar

Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols
Status: Completed Condition: Bacteremia; Tooth Extraction Status Nos

A Pharmacokinetic (PK) Study of Extended-Release Epidural Morphine in Upper Abdominal Surgery
Status: Completed Condition: Postoperative Pain

Fractional Laser Assisted Delivery of Anesthetics
Status: Completed Condition: Local Anesthesia of the Skin.

Comparison Between Two Different Volumes of Anesthesia Drug in Forearm Surgery
Status: Completed Condition: Forearm and Arm Surgery

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage
Status: Terminated Condition: Abscess

Trial of New Pretreatment Method in Transnasal Endoscopy
Status: Completed Condition: Pretreatment Method of Transnasal Endoscopy

Ultrasound-guided Supraclavicular Brachial Plexus Blockade
Status: Recruiting Condition: Pain

Bupivacaine Versus Lidocaine on Inflammatory Regulation Following Endodontic Surgery
Status: Completed Condition: Pain

Evaluation of the Success Rate of Pulpal Anesthesia in Mandibular First Molar Following Infiltration of 4% Articaine Alone and as Supplemental Injection After Inferior Alveolar Nerve Block
Status: Completed Condition: Pulpal Anesthesia

US Guided Axillary Block With Only One Injection
Status: Not yet recruiting Condition: Anesthesia

Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
Status: Completed Condition: Pain

Single Shot Versus OnQ Pump in Extremity Fractures
Status: Recruiting Condition: Pain; Fracture

Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Status: Recruiting Condition: Pain

Incident and Extent of Pulse Alteration During Local Anesthesia in Children
Status: Not yet recruiting Condition: Tachycardia

Fat Grafting for Pedal Fat Pad Atrophy
Status: Active, not recruiting Condition: Pedal Fat Pad Atrophy

Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid
Status: Recruiting Condition: Blepharoptosis

Analgesic Efficacy of Intravenous Lidocaine for Postoperative Pain Following Adult Spine Surgery
Status: Suspended Condition: Back Pain

Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients
Status: Enrolling by invitation Condition: Corneal Ulcer

Evaluation of Oral Midazolam in First-trimester Surgical Abortions
Status: Completed Condition: Pain; Anxiety; Nausea

Lidocaine Spray Compared With Submucosal Injection During LEEP: a Randomized Controlled Trial
Status: Completed Condition: Uterine Cervical Dysplasia

Optimal Time Delay of Epinephrine Injection With "One-per-mil" Tumescent Solution
Status: Enrolling by invitation Condition: Ischemia

TAP Block for Open Radical Prostatectomy.
Status: Suspended Condition: Opioid Consumption; Incidence of Nausea and Vomiting; Postoperative Pain; Assessment of Recovery

Assessment of the Operative Course in Connection With Removal of Lower Third Molars
Status: Completed Condition: Postoperative Pain; Inflammation

Effect of Local Anesthetic on Hemodynamic Measures During Nasal Surgery
Status: Withdrawn Condition: Heart Rate; Blood Pressure; Blood Loss During Surgery; Surgical Field

Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Status: Completed Condition: Irreversible Pulpitis

Effect of Buffered Numbing Solution on Patients With Toothaches
Status: Completed Condition: Irreversible Pulpitis (Toothache)

Anesthetic Efficacy in Irreversible Pulpitis
Status: Completed Condition: Anesthesia

Bupivacaine Versus Lidocaine Local Anesthesia
Status: Recruiting Condition: Carpal Tunnel Syndrome; Trigger Finger

Safety and Efficacy of Lidocaine Infiltration in Suction Assisted Lipectomy
Status: Enrolling by invitation Condition: Healthy

Pain Relief Effects on Length of Labor
Status: Completed Condition: Labor Pain

Formulations of Liposomal Local Anesthetics
Status: Completed Condition: Underdosing of Local Anesthetics, Initial Encounter

Hematoma Block as an Adjunct to Procedural Sedation for Forearm Fracture Reduction
Status: Terminated Condition: Forearm Fracture

Efficacy of Epidural Steroid for Controlling Pain After Primary TKA
Status: Recruiting Condition: Postoperative Pain

Local Anaesthesia vs Regional Block for Arteriovenous Fistulae
Status: Recruiting Condition: End Stage Renal Disease

Comparison of Lidocaine Spray and Paracervical Block Application for Pain Relief During First-trimester Surgical Abortion: a Randomized, Double-blind, Placebo-controlled Trial
Status: Completed Condition: Pain Score

Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion
Status: Withdrawn Condition: Total Knee Arthroplasty

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth
Status: Completed Condition: Healthy; Inflammation; Mouth Disease; Pain

Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain
Status: Terminated Condition: Pain; Nausea

Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients
Status: Enrolling by invitation Condition: Oral Hemorrhage

Comparison of Perfusion Index, T Wave Amplitude, Systolic Blood Pressure and Heart Rate
Status: Recruiting Condition: Injections, Intravenous

Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee
Status: Completed Condition: Knee Osteoarthritis

Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery
Status: Completed Condition: Analgesia

Epidural Calcitonin in Lower Limb Amputation
Status: Active, not recruiting Condition: Amputation; Partial Removal of Lower Limb; Total Removal of Lower Limb

Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia
Status: Completed Condition: Labor; Analgesia, Epidural

Dermatosis Papulosa Nigra
Status: Completed Condition: Facial Dermatoses; Seborrheic Keratoses

A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction
Status: Completed Condition: Patients With Chronic Rhinitis Who Failed Medical Treatment

A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis
Status: Enrolling by invitation Condition: Osteoarthritis, Knee

Local or Regional or General Anesthesia for Hernia Repair: a Randomized Controlled Trial
Status: Recruiting Condition: Hernia; Anesthetics Adverse Reaction; Inflammation

Recalcitrant Pruritus in Cutaneous T-Cell Lymphoma
Status: Terminated Condition: Cutaneous T-Cell Lymphoma

EMLA Topical Anesthetic During Scaling and Root Planing
Status: Completed Condition: Local Anesthesia; Pain, Postoperative; Self-Perception

Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques
Status: Recruiting Condition: Anesthesia; Reaction; Pain

Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain
Status: Recruiting Condition: Pain

Vessel Sealing System Uvulopalatoplasty Versus Uvulopalatal Flap
Status: Enrolling by invitation Condition: Snoring; Obstructive Sleep Apnea

Postoperative Pain Management After Minimally Invasive Esophagectomy
Status: Not yet recruiting Condition: Esophageal Cancer

Ultrasound Guided Blockade of the Lumbar Plexus - the Supra Sacral Parallel Shift
Status: Completed Condition: Hip Fracture

Safety Evaluation of Dexmedetomidine for EBUS-TBNA
Status: Recruiting Condition: Lung Cancer

Endoscopic-guided Versus Cotton-tipped Applicator Gauze Pledgetting for Nasal Anesthesia Before Transnasal Endoscopy
Status: Recruiting Condition: Methods of Nasal Anesthesia Before Transnasal Endoscopy; Side Effects of Transnasal Endoscopy; Patient's Tolerance to Transnasal Endoscopy

Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow
Status: Recruiting Condition: Open Angle Glaucoma

Comparison of Efficacy of Paravertebral and Epidural Analgesia After Videothoracoscopic Lung Lobectomy
Status: Recruiting Condition: Lung Cancer

Study of NV-101 for Safety and Efficacy in Pediatric Dental Patients Undergoing Procedures
Status: Completed Condition: Anesthesia, Dental

Prolotherapy for the Treatment of Plantar Fasciitis
Status: Not yet recruiting Condition: Plantar Fasciitis

Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Status: Recruiting Condition: Anesthetic Effectiveness.

Tumescent Antibiotic Delivery Pharmacokinetics
Status: Completed Condition: Prevention of Surgical Site Infections

Courtesy of
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
epinephrine; lidocaine hydrochloride
PATCH;IONTOPHORESIS, TOPICAL021504May 6, 2004DISCNNo6,635,045<disabled>YY<disabled>
Dell Labs
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION083389Approved Prior to Jan 1, 1982DISCNNo<disabled><disabled>
Bel Mar
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION080757Approved Prior to Jan 1, 1982DISCNNo<disabled><disabled>
Dell Labs
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION083390Approved Prior to Jan 1, 1982DISCNNo<disabled><disabled>
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION089644Jun 21, 1988RXNo<disabled><disabled>
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Preferred citation:
Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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