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Details for Generic Name: epinephrine; lidocaine hydrochloride

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Epinephrine; lidocaine hydrochloride is the generic ingredient in nine branded drugs marketed by Carlisle, Eastman Kodak, Graham Chem, Hikma Maple , Hospira, Abbott, Bel Mar, Dell Labs, Intl Medication, Watson Labs, Pharmaton, Septodont, Dentsply Pharm, Astrazeneca, Fresenius Kabi Usa, Vyteris, Iomed, and Empi, and is included in thirty-one NDAs. There are two patents protecting this compound. Additional information is available in the individual branded drug profile pages.

This ingredient has eight patent family members in seven countries.

There are fourteen drug master file entries for epinephrine; lidocaine hydrochloride. Five suppliers are listed for this compound.

Summary for Generic Name: epinephrine; lidocaine hydrochloride

Drug Master File Entries: see list14
Suppliers: see list5
Formulation / Manufacturing:see details

Pharmacology for Ingredient: epinephrine; lidocaine hydrochloride

Clinical Trials for: epinephrine; lidocaine hydrochloride

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine
Status: Recruiting Condition: Pain, Postoperative

Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery
Status: Recruiting Condition: Carpal Tunnel Syndrome

Gluing Lacerations Utilizing Epinephrine
Status: Completed Condition: Lacerations

Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits
Status: Completed Condition: Irreversible Pulpitis; Pain

Tumescent Lidocaine Maximum Safe mg/kg Dosage
Status: Enrolling by invitation Condition: Anesthesia

Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Nasal Sephoplasty Surgery.
Status: Completed Condition: Surgery; Pain

Comparison of Epinephrine-lidocaine Solution and Dexmedetomidine -Lidocaine Solution
Status: Completed Condition: Craniotomy

Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in Healthy Adult Volunteers
Status: Completed Condition: Local Anesthesia

Anesthesia With Epinephrine in Diabetes Patients is Safe and Effective
Status: Completed Condition: Type 2 Diabetes Mellitus; Coronary Disease

Effect of Sufentanil on the Rate of Anesthesia
Status: Completed Condition: Irreversible Pulpitis

The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Status: Completed Condition: Pain

Effectiveness Study of Different Local Anesthetic Mixtures
Status: Completed Condition: Pain

Effect of Fentanyl on the Rate of Anesthesia
Status: Completed Condition: Painful Irreversible Pulpitis

Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia
Status: Completed Condition: Anesthesia

Efficacy of Buffered Lidocaine in Patients With Facial Swelling
Status: Completed Condition: Facial Swelling

Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease
Status: Completed Condition: Rheumatic Heart Disease; Pregnancy; Dental Caries

Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis
Status: Completed Condition: Local Anesthesia

A Comparison of Tumescence in Breast Reduction Surgery
Status: Recruiting Condition: Pain, Postoperative; Postoperative Nausea and Vomiting

Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning
Status: Terminated Condition: Pain and Discomfort During Scaling and Root Planning of Patients With; Periodontitis

The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Status: Not yet recruiting Condition: Chronic Sinusitis

Use of Recombinant Hyaluronidase Human is Effective for the Use of Local Blocks for Eyelid's Surgery
Status: Withdrawn Condition: Upper Eyelid Surgery

Saline Injection - Assisted Anesthesia in Eyelid Surgery
Status: Recruiting Condition: Blepharoptosis

Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)
Status: Completed Condition: Uterine Cervical Dysplasia

The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.
Status: Recruiting Condition: Epistaxis; Blood Pressure

Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
Status: Enrolling by invitation Condition: Anesthesia

Three-level Injection Paravertebral Block vs General Anesthesia in Mastectomy
Status: Completed Condition: Radical Mastectomy

The Efficacy of Analgesic Buffering With Sodium Bicarbonate for the Pediatric Dental Patient
Status: Recruiting Condition: Pediatric Dentistry

Dental Anesthesia in Heart Failure Patients
Status: Not yet recruiting Condition: Heart Failure

The Simultaneous Use of Supraclavicular and Distal Blocks
Status: Completed Condition: Orthopaedic Disorders; Nerve Block; Anaesthesia

Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
Status: Completed Condition: Acute Otitis Media; Chronic Otitis Media; Recurrent Acute Otitis Media

Anesthesia for Dental Treatment in Cardiac Patients: Lidocaine Comparative Study
Status: Completed Condition: Arrhythmias; Anxiety

Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
Status: Enrolling by invitation Condition: Diabetes Mellitus; Local Anesthesia

Does Intraperitoneal Instillation of Lidocaine at Cesarean Delivery Improve Postoperative Analgesia?
Status: Recruiting Condition: Pain

Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
Status: Completed Condition: Methemoglobinemia

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage
Status: Terminated Condition: Abscess

Reducing Side-effects of Autologous Skin Tissue Harvesting
Status: Not yet recruiting Condition: Scar

Evaluation of the Success Rate of Pulpal Anesthesia in Mandibular First Molar Following Infiltration of 4% Articaine Alone and as Supplemental Injection After Inferior Alveolar Nerve Block
Status: Completed Condition: Pulpal Anesthesia

Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Status: Completed Condition: Anesthetic Effectiveness

Bupivacaine Versus Lidocaine on Inflammatory Regulation Following Endodontic Surgery
Status: Completed Condition: Pain

Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
Status: Completed Condition: Syncope, Vasovagal; Pain Intensity

Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Status: Recruiting Condition: Pain

Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
Status: Completed Condition: Pain

Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols
Status: Completed Condition: Bacteremia; Tooth Extraction Status Nos

A Pharmacokinetic (PK) Study of Extended-Release Epidural Morphine in Upper Abdominal Surgery
Status: Completed Condition: Postoperative Pain

Incident and Extent of Pulse Alteration During Local Anesthesia in Children
Status: Not yet recruiting Condition: Tachycardia

Analgesic Efficacy of Intravenous Lidocaine for Postoperative Pain Following Adult Spine Surgery
Status: Withdrawn Condition: Back Pain

Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine
Status: Completed Condition: Open Reduction Internal Fixation(ORIF) of Lateral Malleolus

Comparison Between Two Different Volumes of Anesthesia Drug in Forearm Surgery
Status: Completed Condition: Forearm and Arm Surgery

Ultrasound-guided Supraclavicular Brachial Plexus Blockade
Status: Recruiting Condition: Pain

Fractional Laser Assisted Delivery of Anesthetics
Status: Completed Condition: Local Anesthesia of the Skin.

Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid
Status: Recruiting Condition: Blepharoptosis

US Guided Axillary Block With Only One Injection
Status: Not yet recruiting Condition: Anesthesia

Trial of New Pretreatment Method in Transnasal Endoscopy
Status: Completed Condition: Pretreatment Method of Transnasal Endoscopy

Evaluation of Oral Midazolam in First-trimester Surgical Abortions
Status: Completed Condition: Pain; Anxiety; Nausea

Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients
Status: Enrolling by invitation Condition: Corneal Ulcer

Shamrock Versus Lumbar Ultrasound Trident - Ultrasound Guided Block of the Lumbar Plexus
Status: Not yet recruiting Condition: Hip Fractures; Anesthesia Local; Pain, Postoperative

Single Shot Versus OnQ Pump in Extremity Fractures
Status: Recruiting Condition: Pain; Fracture

Lidocaine Spray Compared With Submucosal Injection During LEEP: a Randomized Controlled Trial
Status: Completed Condition: Uterine Cervical Dysplasia

Fat Grafting for Pedal Fat Pad Atrophy
Status: Active, not recruiting Condition: Pedal Fat Pad Atrophy

Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Status: Completed Condition: Irreversible Pulpitis

TAP Block for Open Radical Prostatectomy.
Status: Terminated Condition: Opioid Consumption; Incidence of Nausea and Vomiting; Postoperative Pain; Assessment of Recovery

Optimal Time Delay of Epinephrine Injection With "One-per-mil" Tumescent Solution
Status: Enrolling by invitation Condition: Ischemia

Effect of Buffered Numbing Solution on Patients With Toothaches
Status: Completed Condition: Irreversible Pulpitis (Toothache)

Safety and Efficacy of Lidocaine Infiltration in Suction Assisted Lipectomy
Status: Enrolling by invitation Condition: Healthy

Assessment of the Operative Course in Connection With Removal of Lower Third Molars
Status: Completed Condition: Postoperative Pain; Inflammation

Effect of Local Anesthetic on Hemodynamic Measures During Nasal Surgery
Status: Withdrawn Condition: Heart Rate; Blood Pressure; Blood Loss During Surgery; Surgical Field

Anesthetic Efficacy in Irreversible Pulpitis
Status: Completed Condition: Anesthesia

Hematoma Block as an Adjunct to Procedural Sedation for Forearm Fracture Reduction
Status: Terminated Condition: Forearm Fracture

Bupivacaine Versus Lidocaine Local Anesthesia
Status: Recruiting Condition: Carpal Tunnel Syndrome; Trigger Finger

Pain Relief Effects on Length of Labor
Status: Completed Condition: Labor Pain

Comparison of Lidocaine Spray and Paracervical Block Application for Pain Relief During First-trimester Surgical Abortion: a Randomized, Double-blind, Placebo-controlled Trial
Status: Completed Condition: Pain Score

Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion
Status: Withdrawn Condition: Total Knee Arthroplasty

Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain
Status: Terminated Condition: Pain; Nausea

Formulations of Liposomal Local Anesthetics
Status: Completed Condition: Underdosing of Local Anesthetics, Initial Encounter

Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery
Status: Completed Condition: Analgesia

Efficacy of Epidural Steroid for Controlling Pain After Primary TKA
Status: Recruiting Condition: Postoperative Pain

Comparison of Perfusion Index, T Wave Amplitude, Systolic Blood Pressure and Heart Rate
Status: Recruiting Condition: Injections, Intravenous

Local Anaesthesia vs Regional Block for Arteriovenous Fistulae
Status: Recruiting Condition: End Stage Renal Disease

Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia
Status: Completed Condition: Labor; Analgesia, Epidural

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth
Status: Completed Condition: Healthy; Inflammation; Mouth Disease; Pain

Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients
Status: Enrolling by invitation Condition: Oral Hemorrhage

Epidural Calcitonin in Lower Limb Amputation
Status: Active, not recruiting Condition: Amputation Stumps

Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee
Status: Completed Condition: Knee Osteoarthritis

Dermatosis Papulosa Nigra
Status: Completed Condition: Facial Dermatoses; Seborrheic Keratoses

A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis
Status: Enrolling by invitation Condition: Osteoarthritis, Knee

EMLA Topical Anesthetic During Scaling and Root Planing
Status: Completed Condition: Local Anesthesia; Pain, Postoperative; Self-Perception

Recalcitrant Pruritus in Cutaneous T-Cell Lymphoma
Status: Terminated Condition: Cutaneous T-Cell Lymphoma

Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques
Status: Recruiting Condition: Anesthesia; Reaction; Pain

Vessel Sealing System Uvulopalatoplasty Versus Uvulopalatal Flap
Status: Enrolling by invitation Condition: Snoring; Obstructive Sleep Apnea

Local or Regional or General Anesthesia for Hernia Repair: a Randomized Controlled Trial
Status: Recruiting Condition: Hernia; Anesthetics Adverse Reaction; Inflammation

A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction
Status: Completed Condition: Patients With Chronic Rhinitis Who Failed Medical Treatment

Postoperative Pain Management After Minimally Invasive Esophagectomy
Status: Not yet recruiting Condition: Esophageal Cancer

Prolotherapy for the Treatment of Plantar Fasciitis
Status: Not yet recruiting Condition: Plantar Fasciitis

Comparison of Efficacy of Paravertebral and Epidural Analgesia After Videothoracoscopic Lung Lobectomy
Status: Recruiting Condition: Lung Cancer

Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
Status: Completed Condition: Cleft Palate

Endoscopic-guided Versus Cotton-tipped Applicator Gauze Pledgetting for Nasal Anesthesia Before Transnasal Endoscopy
Status: Recruiting Condition: Methods of Nasal Anesthesia Before Transnasal Endoscopy; Side Effects of Transnasal Endoscopy; Patient's Tolerance to Transnasal Endoscopy

Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches
Status: Completed Condition: Postoperative Pain

A Study Comparing Continuous Sciatic Nerve Block to Single Shot Sciatic Nerve Block
Status: Recruiting Condition: Foot Surgery

Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow
Status: Recruiting Condition: Open Angle Glaucoma

Study of NV-101 for Safety and Efficacy in Pediatric Dental Patients Undergoing Procedures
Status: Completed Condition: Anesthesia, Dental

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See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION089649-001Jun 21, 1988DISCNNo<disabled><disabled>
Fresenius Kabi Usa
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION006488-005Approved Prior to Jan 1, 1982RXYes<disabled><disabled>
Dentsply Pharm
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION021381-001Approved Prior to Jan 1, 1982DISCNNo<disabled><disabled>
Watson Labs
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION085463-001Approved Prior to Jan 1, 1982DISCNNo<disabled><disabled>
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION084048-001Approved Prior to Jan 1, 1982RXYes<disabled><disabled>
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International Patent Family for Ingredient: epinephrine; lidocaine hydrochloride

Country Document Number Publication Date
Canada2413624Jan 10, 2002
Germany60129965Sep 27, 2007
European Patent Office1294439Mar 26, 2003
World Intellectual Property Organization (WIPO)0202182Jan 10, 2002
Japan2004501727Jan 22, 2004
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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