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Details for Generic Name: epinephrine

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Epinephrine is the generic ingredient in thirty-one branded drugs marketed by Sterling, Armstrong Pharms, Wyeth Cons, Forest Labs, Mylan Speclt, Amedra Pharms, Sanofi Aventis Us, 3M, Astrazeneca, Dentsply Pharm, Deproco, Septodont Inc, Par Sterile Products, Belcher Pharms Llc, Carlisle, Eastman Kodak, Graham Chem, Hikma Maple , Hospira, Abbott, Bel Mar, Dell Labs, Intl Medication, Watson Labs, Pharmaton, Septodont, Fresenius Kabi Usa, Vyteris, Iomed, and Empi, and is included in fifty-one NDAs. There are twenty-six patents protecting this compound and two Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

There are twelve drug master file entries for epinephrine. Eleven suppliers are listed for this compound.

Summary for Generic Name: epinephrine

Tradenames:31
Patents:26
Applicants:30
NDAs:51
Drug Master File Entries: see list12
Suppliers: see list11
Therapeutic Class:Respiratory Tract Agents

Pharmacology for Ingredient: epinephrine

Clinical Trials for: epinephrine

A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine
Status: Completed Condition: Anaphylaxis

Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics
Status: Completed Condition: Asthma; Bronchospasm; Wheezing; Shortness of Breath

Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy Volunteers
Status: Completed Condition: Asthma

Make up for the Epinephrine Autoinjector
Status: Completed Condition: Anaphylaxis

Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Status: Recruiting Condition: Cardiopulmonary Arrest; Cardiac Arrest

The Effect and Safety of Low Dose Nebulized Epinephrine in Croup
Status: Not yet recruiting Condition: Croup; Epinephrine Neublizer Treatment

The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Status: Completed Condition: Spinal Anesthesia

Comparative Evaluation of Handling Characteristics of Two Adrenaline Autoinjectors,EpiPen in Comparison With Jext
Status: Completed Condition: Handling of Auto-injectors

Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59)
Status: Completed Condition: Adrenal Gland Neoplasms; Adrenal Malignancies; Abnormal Hormonal Secretions; Electrolytes Abnormalities

Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation
Status: Completed Condition: Adrenal Gland Neoplasms

ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty
Status: Completed Condition: Spinal Anesthesia; Total Knee Replacement Arthroplasty

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine
Status: Recruiting Condition: Pain, Postoperative

Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy
Status: Recruiting Condition: Thyroid Neoplasm; Goiter

Low-dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients
Status: Completed Condition: Congenital Disorders

Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate
Status: Completed Condition: Adrenal Insufficiency

Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients
Status: Terminated Condition: Renal Insufficiency, Chronic

Comparative Study of Autologous Blood Injection Versus Diluted Epinephrine in Treating Actively Bleeding Gastroduodenal Ulcers
Status: Completed Condition: Blood, Injection, Injury Type Phobia; Gastrointestinal Ulcer Haemorrhage; Adverse Reaction to Epinephrine

Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Status: Not yet recruiting Condition: Hypertension; Hypotension; Tachycardia; Bradycardia; Arrhythmia

Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients
Status: Completed Condition: Asthma

Gluing Lacerations Utilizing Epinephrine
Status: Completed Condition: Lacerations

Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Status: Completed Condition: Adrenal Gland Hypofunction

Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine
Status: Recruiting Condition: Postoperative Pain

Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Status: Recruiting Condition: Asthma

Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults
Status: Terminated Condition: Asthma

Combined Vasopressin, Methylprednisolone, and Epinephrine for Inhospital Cardiac Arrest
Status: Completed Condition: Heart Arrest

Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
Status: Completed Condition: Cardiac Arrest

Anesthesia With Epinephrine in Diabetes Patients is Safe and Effective
Status: Completed Condition: Type 2 Diabetes Mellitus; Coronary Disease

Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
Status: Completed Condition: Cardiac Arrest

Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs
Status: Completed Condition: Healthy

Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma
Status: Completed Condition: Adrenal Cortex Neoplasms

Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery
Status: Completed Condition: Cataract

SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Status: Active, not recruiting Condition: Hyperaldosteronism

Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism
Status: Recruiting Condition: Primary Aldosteronism

The Effects of Epinephrine in Endotoxemia in Normal Volunteers
Status: Completed Condition: Immune System

Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)
Status: Completed Condition: Arthroplasty, Replacement, Hip

Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety
Status: Recruiting Condition: Bronchiolitis

Study Comparing the Efficacy and Tolerability of Epinephrine and Norepinephrine in Cardiogenic Shock
Status: Recruiting Condition: Cardiogenic Shock

Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia
Status: Not yet recruiting Condition: Adrenal Gland Neoplasms

Lipid-poor Adrenal Masses: Evaluation With Chemical Shift MRI
Status: Completed Condition: Adrenal Gland Disease

Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
Status: Terminated Condition: Osteoarthritis

Vasopressin, Epinephrine, and Steroids for Cardiac Arrest
Status: Completed Condition: Cardiac Arrest

Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery
Status: Recruiting Condition: Carpal Tunnel Syndrome

Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Nasal Sephoplasty Surgery.
Status: Completed Condition: Surgery; Pain

Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis
Status: Withdrawn Condition: Sepsis; Adrenal Insufficiency

Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency
Status: Completed Condition: Adrenal Insufficiency

Adrenal Insufficiency in Septic Shock
Status: Terminated Condition: Septic Shock; Acute Adrenal Insufficiency

Visualization in Shoulder Arthroscopy With and Without Epinephrine
Status: Completed Condition: Visualization in Shoulder Arthroscopy

Randomized, Placebo/Active Crossover Dose-ranging Study for Safety and Efficacy in Asthma Patients.
Status: Terminated Condition: Asthma

The Influence of Inhaled Adrenalin Versus Decongestant as a Local Nasal Treatment in Bronchiolitis
Status: Completed Condition: Bronchiolitis

Safety of Epidural Fentanyl and Adrenalin During Childbirth
Status: Active, not recruiting Condition: Pregnancy; Pain

The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Status: Not yet recruiting Condition: Chronic Sinusitis

Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Status: Completed Condition: Hypotension After Reperfusion in Liver Transplantation

Evaluation of Molecular Markers in Adrenal Tumors
Status: Recruiting Condition: Adrenal Gland Neoplasms

Vasopressin Versus Epinephrine in Myomectomy
Status: Recruiting Condition: Uterine Myomas

Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery
Status: Recruiting Condition: Chronic Sinusitis

Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in Healthy Adult Volunteers
Status: Completed Condition: Local Anesthesia

Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study
Status: Recruiting Condition: Adrenal Tumors

Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection
Status: Completed Condition: Tendinopathy; Adrenal Insufficiency

A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency
Status: Recruiting Condition: Chronic Adrenal Insufficiency

The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery
Status: Completed Condition: Intraoperative Blood Loss

Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
Status: Recruiting Condition: Digestive Diseases; Adrenal Insufficiency; Gastrointestinal Bleeding; Variceal Bleeding; Acute Pancreatitis

Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock
Status: Completed Condition: Septic Shock; Severe Sepsis; Infections

Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia
Status: Recruiting Condition: Adrenal Insufficiency; Excess Androgen; Congenital Adrenal Hyperplasia (CAH)

Adrenal Vein Sampling International Study (AVIS Study)
Status: Completed Condition: Hyperaldosteronism

Trial of Epinephrine and Albuterol in Bronchiolitis
Status: Active, not recruiting Condition: Bronchiolitis

Study of UK Adults With Congenital Adrenal Hyperplasia.
Status: Completed Condition: Congenital Adrenal Hyperplasia

Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
Status: Completed Condition: Cardiac Arrest

Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH
Status: Completed Condition: Endocrine Disease; Adrenal Insufficiency; Congenital Adrenal Hyperplasia

Adrenal Function in Critical Illness
Status: Completed Condition: Adrenal Insufficiency

A Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in High Risk Patients
Status: Recruiting Condition: Post-ERCP Acute Pancreatitis

Comparison of Epinephrine-lidocaine Solution and Dexmedetomidine -Lidocaine Solution
Status: Completed Condition: Craniotomy

Comparison of Perfusion Index, T Wave Amplitude, Systolic Blood Pressure and Heart Rate
Status: Recruiting Condition: Injections, Intravenous

Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
Status: Recruiting Condition: Long QT Syndrome Type 1 or 2

Plasma Concentrations of Levobupivacaine With and Without Epinephrine in Transversus Abdominis Plane Blocks
Status: Completed Condition: Transversus Abdominis Plane Block

Cardiovascular Risk Profile in Patients With Congenital Adrenal Hyperplasia
Status: Recruiting Condition: Congenital Adrenal Hyperplasia

Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Bronchiolitis.
Status: Completed Condition: Bronchiolitis

Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
Status: Completed Condition: Adrenal Gland Hyperfunction; Adrenal Gland Hypofunction; Cushing's Syndrome; Healthy

Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening
Status: Completed Condition: Adrenal Gland Diseases; Adrenal Gland Neoplasms

Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia
Status: Recruiting Condition: Adrenal Hyperplasia, Congenital

Adrenal Function in Patients With Newly Diagnosed Lung Cancer
Status: Completed Condition: Lung Cancer; Adrenal Insufficiency

Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study
Status: Terminated Condition: Rsv Bronchiolitis

Adrenal Hyperplasia Among Young People With PCOS
Status: Completed Condition: Adrenal Hyperplasia; Polycystic Ovarian Syndrome; Oligomenorrhea; Obesity; Hyperandrogenism

Catecholamine Reserve and Exercise Tolerance in Healthy Volunteers and Patients With Congenital Adrenal Hyperplasia
Status: Completed Condition: Congenital Adrenal Hyperplasia; Healthy

Bupivacaine Injections Into Uterosacral Ligaments During Robotic Assisted Total Hysterectomies
Status: Not yet recruiting Condition: Pain

Epinephrine Inhalation Aerosol USP, CLINICAL STUDY-B3 FOR ASSESSMENT OF PHARMACOKINETICS
Status: Completed Condition: Asthma

Dose Study of Tuberculin Purified Protein Derivative (JHP/Dose)
Status: Recruiting Condition: Tuberculosis Infection

Blueberry Effects on Dark Vision and Glare Recovery
Status: Completed Condition: Blindness and Low Vision

Adrenalectomy for Solitary Adrenal Gland Metastases
Status: Completed Condition: Adrenal Gland Metastases; Adrenalectomy

Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Status: Withdrawn Condition: Type 1 Diabetes

Effect of Sufentanil on the Rate of Anesthesia
Status: Completed Condition: Irreversible Pulpitis

Adrenal Tumors - Pathogenesis and Therapy
Status: Recruiting Condition: Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma

Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease
Status: Completed Condition: Rheumatic Heart Disease; Pregnancy; Dental Caries

Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency
Status: Completed Condition: Adrenal Insufficiency

The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain
Status: Recruiting Condition: Pain, Postoperative; Postoperative Hemorrhage

Comparative Study, Safety and Efficacy, Ahmed Glaucoma Drainage Device, Model M4 Model S2 in Neovascular Glaucoma
Status: Active, not recruiting Condition: Neovascular Glaucoma

The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung Diseases
Status: Not yet recruiting Condition: Adrenal Insufficiency; Inflammatory Lung Diseases

Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia
Status: Active, not recruiting Condition: Congenital Adrenal Hyperplasia; Growth Disorder

Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy.
Status: Recruiting Condition: Adrenal Suppression

Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I
Status: Completed Condition: Addison's Disease; Adrenal Insufficiency; Diabetes Mellitus Type I

Research Study for Children With Salt Wasting Congenital Adrenal Hyperplasia
Status: Completed Condition: Adrenal Hyperplasia, Congenital

Courtesy of ClinicalTrials.org
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Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Sanofi Aventis Us
AUVI-Q
epinephrine
INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS201739Aug 10, 2012RXYes8,361,029<disabled>Y<disabled>
Sanofi Aventis Us
AUVI-Q
epinephrine
INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS201739Aug 10, 2012RXNo8,361,029<disabled>Y<disabled>
Vyteris
LIDOSITE TOPICAL SYSTEM KIT
epinephrine; lidocaine hydrochloride
PATCH;IONTOPHORESIS, TOPICAL021504May 6, 2004DISCNNo6,629,968<disabled>YY<disabled>
Carlisle
ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE
epinephrine; lidocaine hydrochloride
INJECTABLE;INJECTION084720Approved Prior to Jan 1, 1982DISCNNo<disabled><disabled>
Mylan Speclt
EPIPEN JR.
epinephrine
INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS019430Dec 22, 1987RXYes7,449,012<disabled>Y<disabled>
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