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Details for Generic Name: aprepitant

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Aprepitant is the generic ingredient in two branded drugs marketed by Sandoz, Merck, and Msd Merck Co, and is included in three NDAs. There are three patents protecting this compound and three Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

This ingredient has one hundred and seventy-five patent family members in fifty-two countries.

There are eighteen drug master file entries for aprepitant. Three suppliers are listed for this compound.

Summary for Generic Name: aprepitant

Tradenames:2
Patents:3
Applicants:3
NDAs:3
Drug Master File Entries: see list18
Suppliers / Packaging: see list13
Therapeutic Class:Antiemetics

Clinical Trials for: aprepitant

Efficacy of Aprepitant (Emend®) in Children
Status: Recruiting Condition: Nausea; Vomiting; Childhood Cancer

Topical Aprepitant in Prurigo Patients
Status: Completed Condition: Pruritus

A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
Status: Terminated Condition: Chemotherapy-Induced Nausea and Vomiting

Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
Status: Completed Condition: Lymphoma

Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy
Status: Completed Condition: Chemotherapy Induced Nausea and Vomiting

Pharmacokinetic Characteristics and Anti-Inflammatory Effects of Aprepitant In HIV-Infected Subjects
Status: Recruiting Condition: HIV Infection

A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)
Status: Completed Condition: Postoperative Nausea and Vomiting

Aprepitant Effects on Oxycodone Response
Status: Completed Condition: Narcotic Abuse

Courtesy of ClinicalTrials.org
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Msd Merck Co
EMEND
aprepitant
FOR SUSPENSION;ORAL207865-001Dec 17, 2015RXYes<disabled><disabled>
Merck
EMEND
aprepitant
CAPSULE;ORAL021549-002Mar 26, 2003RXYes<disabled><disabled>
Merck
EMEND
aprepitant
CAPSULE;ORAL021549-002Mar 26, 2003RXYes6,096,742<disabled>YY <disabled>
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Expired Orange Book Patents for Generic Ingredient: aprepitant

These historical archives are available as an add-on to one-year subscriptions

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Merck
EMEND
aprepitant
CAPSULE;ORAL021549-003Jun 30, 20066,235,735<disabled>
Merck
EMEND
aprepitant
CAPSULE;ORAL021549-003Jun 30, 20065,145,684<disabled>
Merck
EMEND
aprepitant
CAPSULE;ORAL021549-001Mar 26, 20035,145,684<disabled>
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International Patent Family for Ingredient: aprepitant

Country Document Number Publication Date
TaiwanI249403Feb 21, 2006
Colombia4340628Jul 30, 1996
World Intellectual Property Organization (WIPO)03049718Jun 19, 2003
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.

Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided information. There is no warranty that the information contained herein is error free. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2016 thinkBiotech LLC
ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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