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Details for Generic Name: aprepitant

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Aprepitant is the generic ingredient in two branded drugs marketed by Sandoz and Merck, and is included in two NDAs. There are three patents protecting this compound and three Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

There are fifteen drug master file entries for aprepitant. Three suppliers are listed for this compound.

Summary for Generic Name: aprepitant

Drug Master File Entries: see list15
Suppliers: see list3
Therapeutic Class:Antiemetics
Formulation / Manufacturing:see details

Clinical Trials for: aprepitant

Efficacy of Aprepitant (Emend®) in Children
Status: Recruiting Condition: Nausea; Vomiting; Childhood Cancer

Topical Aprepitant in Prurigo Patients
Status: Completed Condition: Pruritus

A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
Status: Terminated Condition: Chemotherapy-Induced Nausea and Vomiting

Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
Status: Completed Condition: Lymphoma

Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy
Status: Completed Condition: Chemotherapy Induced Nausea and Vomiting

Pharmacokinetic (PK) Characteristics and Anti-Inflammatory Effects of the NK-1R Antagonist, Aprepitant, In HIV-Infected Subjects With Undetectable Viral Load Receiving Atazanavir/Ritonavir Or Darunavir/Ritonavir-Containing Antiretroviral Therapy
Status: Recruiting Condition: HIV Infection

A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)
Status: Completed Condition: Postoperative Nausea and Vomiting

Aprepitant Effects on Oxycodone Response
Status: Completed Condition: Narcotic Abuse

A Study to Evaluate Aprepitant for the Prevention of Post Operative Nausea and Vomiting in Children (MK-0869-219)
Status: Recruiting Condition: Post-Operative Nausea; Post-Operative Vomiting

Aprepitant and Fosaprepitant Time-on-Target PET (Positron Emission Tomography) Study (0869-183)
Status: Completed Condition: Chemotherapy-Induced Nausea and Vomiting (CINV)

Courtesy of
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
CAPSULE;ORAL021549-002Mar 26, 2003RXYes6,096,742<disabled>YY<disabled>
CAPSULE;ORAL090999-002Sep 24, 2012RXNo<disabled><disabled>
CAPSULE;ORAL021549-003Jun 30, 2006RXNo6,096,742<disabled>YY<disabled>
CAPSULE;ORAL090999-001Sep 24, 2012RXNo<disabled><disabled>
CAPSULE;ORAL021549-001Mar 26, 2003RXNo6,096,742<disabled>YY<disabled>
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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