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Details for Generic Name: aprepitant

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Aprepitant is the generic ingredient in two branded drugs marketed by Sandoz and Merck, and is included in two NDAs. There are three patents protecting this compound and three Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

This ingredient has one hundred and seventy-three patent family members in fifty-two countries.

There are eighteen drug master file entries for aprepitant. Three suppliers are listed for this compound.

Summary for Generic Name: aprepitant

Drug Master File Entries: see list18
Suppliers / Packaging: see list13
Therapeutic Class:Antiemetics

Clinical Trials for: aprepitant

Efficacy of Aprepitant (Emend®) in Children
Status: Recruiting Condition: Nausea; Vomiting; Childhood Cancer

Topical Aprepitant in Prurigo Patients
Status: Completed Condition: Pruritus

A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
Status: Terminated Condition: Chemotherapy-Induced Nausea and Vomiting

Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
Status: Completed Condition: Lymphoma

Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy
Status: Completed Condition: Chemotherapy Induced Nausea and Vomiting

Pharmacokinetic Characteristics and Anti-Inflammatory Effects of Aprepitant In HIV-Infected Subjects
Status: Recruiting Condition: HIV Infection

A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)
Status: Completed Condition: Postoperative Nausea and Vomiting

Aprepitant Effects on Oxycodone Response
Status: Completed Condition: Narcotic Abuse

A Study to Evaluate Aprepitant for the Prevention of Post Operative Nausea and Vomiting in Children (MK-0869-219)
Status: Recruiting Condition: Post-Operative Nausea; Post-Operative Vomiting

Aprepitant and Fosaprepitant Time-on-Target PET (Positron Emission Tomography) Study (0869-183)
Status: Completed Condition: Chemotherapy-Induced Nausea and Vomiting (CINV)

Courtesy of
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
CAPSULE;ORAL021549-002Mar 26, 2003RXYes6,096,742<disabled>YY <disabled>
CAPSULE;ORAL090999-002Sep 24, 2012RXNo<disabled><disabled>
CAPSULE;ORAL090999-003Sep 24, 2012RXNo<disabled><disabled>
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International Patent Family for Ingredient: aprepitant

Country Document Number Publication Date
Norway996549Dec 29, 1999
Germany69326977Dec 16, 1999
Russian Federation94046364Oct 10, 1996
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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