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Details for Patent: 5,587,497

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Summary for Patent: 5,587,497

Title: 19-nor-vitamin D compounds
Abstract:This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided. The 19-nor vitamin D compounds have the formula: ##STR1## where X.sup.1 and X.sup.2 are each hydrogen or a hydroxy protecting group and R is a side chain.
Inventor(s): DeLuca; Hector F. (Deerfield, WI), Schnoes; Heinrich K. (Madison, WI), Perlman; Kato L. (Madison, WI), Sicinski; Rafal R. (Warsaw, PL), Prahl; Jean M. (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Application Number:08/442,492
Patent Claim Types:
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Compound;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,587,497

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina246254<disabled in preview>
Austria100447<disabled in preview>
Austria173401<disabled in preview>
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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