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Details for Patent: 5,407,914

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Summary for Patent: 5,407,914

Title: Pulmonary surfactant protein and related polypeptides
Abstract:The present invention discloses useful peptides and synthetic pulmonary surfactants, as well as methods of making and using same. In a preferred embodiment, a synthetic pulmonary surfactant comprises one or more pharmaceutically acceptable phospholipids admixed with a polypeptide comprising at least 10 amino acid residues and no more than about 60 amino acid residues, said polypeptide including a sequence having alternating hydrophobic and hydrophilic amino acid residue regions. In other embodiments, a surfactant peptide has an amino acid residue sequence selected from the group consisting of KLLLLKLLLLKLLLLKLLLLK, KLLLLLLLLKLLLLLLLLKLL, and KKLLLLLLLKKLLLLLLLKKL.
Inventor(s): Cochrane; Charles G. (La Jolla, CA), Revak; Susan D. (San Diego, CA)
Assignee: The Scripps Research Institute (La Jolla, CA)
Application Number:08/060,833
Patent Claim Types:
see list of patent claims
Compound; Use;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,407,914

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria196298<disabled in preview>
Austria199730<disabled in preview>
Austria223436<disabled in preview>
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