Details for Patent: 5,352,459

Summary for Patent: 5,352,459

Title:	Use of purified surface modifiers to prevent particle aggregation during sterilization
Abstract:	This invention discloses a composition comprised of nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. Preferred purified polymeric surfactants are purified polyalkyleneoxide substituted ethylenediamine surfactants. A preferred cloud point modifier is polyethylene glycol. This invention further discloses a method of making nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface and a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
Inventor(s):	Hollister; Kenneth R. (Chester Springs, PA), Ladd; David (Wayne, PA), McIntire; Gregory L. (West Chester, PA), Na; George C. (Fort Washington, PA), Rajagopalan; Natarajan (Phoenixville, PA), Yuan; Barbara O. (Villanova, PA)
Assignee:	Sterling Winthrop Inc. (New York, NY)
Application Number:	07/991,639
Patent Claim Types: see list of patent claims	Composition; Use;

Drugs Protected by US Patent 5,352,459

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 5,352,459

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	5046693
Australia	663010
Canada	2102356
Czech Republic	9302616
European Patent Office	0605024