Details for Patent: 4,695,578
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Summary for Patent: 4,695,578
| Title: | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
| Abstract: | The invention relates to compounds of formula (I). ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group, and one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-(C.sub.1-3) alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; and physiologically acceptable salts and solvates, e.g. hydrates thereof. The compounds are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia. |
| Inventor(s): | Coates; Ian H. (Hertfordshire, GB2), Bell; James A. (Royston, GB2), Humber; David C. (Ealing, GB2), Ewan; George B. (Gerrard's Cross, GB2) |
| Assignee: | Glaxo Group Limited (London, GB2) |
| Application Number: | 06/931,032 |
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Patent Claim Types: see list of patent claims | Compound; Use; Composition; |
Drugs Protected by US Patent 4,695,578
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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Foreign Priority and PCT Information for Patent: 4,695,578
International Family Members for US Patent 4,695,578
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Austria | 392276 | ⤷ Try a Trial | |||
| Austria | A20485 | ⤷ Try a Trial | |||
| Australia | 3809785 | ⤷ Try a Trial | |||
| Australia | 5261486 | ⤷ Try a Trial | |||
| Australia | 579132 | ⤷ Try a Trial | |||
| Australia | 583343 | ⤷ Try a Trial | |||
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