Details for Patent: 4,089,969
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Summary for Patent: 4,089,969
Title: | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
Abstract: | Novel 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R is hydrogen or a lower alkyl group containing from 1 to 4 carbon atoms and R.sup.1 is hydrogen, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group of 1 to 4 carbon atoms, chloro, fluoro or bromo, the R.sup.1 substitution being at the ortho, meta or para positions of the aroyl group and process for the production of such compounds; 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is representative of the class. These compounds, as the racemic mixture or the (1)-isomer, are useful as anti-inflammatory, analgesic and antipyretic agents and as smooth muscle relaxants. |
Inventor(s): | Muchowski; Joseph M. (Mexico City, MX), Kluge; Arthur F. (Los Altos, CA) |
Assignee: | Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Application Number: | 05/771,286 |
Patent Claim Types: see list of patent claims | Compound; Use; Composition; Delivery; |
Drugs Protected by US Patent 4,089,969
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