You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Details for Patent: 8,674,112


✉ Email this page to a colleague

« Back to Dashboard


Title:Polymorph of a pharmaceutical
Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
Inventor(s): Bauer; John F. (Lake Bluff, IL), Saleki-Gerhardt; Azita (Libertyville, IL), Narayanan; Bikshandarkoil A. (Newton, CT), Chemburkar; Sanjay R. (Gurnee, IL), Patel; Ketan M. (Wheeling, IL), Spiwek; Harry O. (Kenosha, WI), Bauer; Philip E. (Chester Springs, PA), Allen; Kimberly A. (Trevor, WI)
Assignee: AbbVie Inc. (North Chicago, IL)
Filing Date:May 25, 2012
Application Number:13/480,882
Claims:1. A process for preparing a composition comprising ritonavir, said process comprising dissolving Form II and Form I crystalline ritonavir in a solvent, wherein said Form II crystalline ritonavir has characteristic peaks in a powder X-ray diffraction pattern at values of two theta of 8.67.degree..+-.0.1.degree., 9.88.degree..+-.0.1.degree., 16.11.degree..+-.0.1.degree., 16.70.degree..+-.0.1.degree., 17.36.degree..+-.0.1.degree., 17.78.degree..+-.0.1.degree., 18.40.degree..+-.0.1.degree., 18.93.degree..+-.0.1.degree., 20.07.degree..+-.0.1.degree., 20.65.degree..+-.0.1.degree., 21.71.degree..+-.0.1.degree. and 25.38.degree..+-.0.1.degree., and said Form I crystalline ritonavir has characteristic peaks in a powder X-ray diffraction pattern at values of two theta of 3.33.degree..+-.0.1.degree., 6.76.degree..+-.0.1.degree., 8.33.degree..+-.0.1.degree., 14.61.degree..+-.0.1.degree., 16.33.degree..+-.0.1.degree., 16.76.degree..+-.0.1.degree., 17.03.degree..+-.0.1.degree., 18.02.degree..+-.0.1.degree., 18.62.degree..+-.0.1.degree., 19.47.degree..+-.0.1.degree., 19.86.degree..+-.0.1.degree., 20.25.degree..+-.0.1.degree., 21.46.degree..+-.0.1.degree., 23.46.degree..+-.0.1.degree. and 24.36.degree..+-.0.1.degree..

2. The process of claim 1, wherein said Form II crystalline ritonavir has characteristic peaks in a powder X-ray diffraction pattern at values of two theta of 8.67.degree..+-.0.1.degree., 9.51.degree..+-.0.1.degree., 9.88.degree..+-.0.1.degree., 10.97.degree..+-.0.1.degree., 13.74.degree..+-.0.1.degree., 16.11.degree..+-.0.1.degree., 16.70.degree..+-.0.1.degree., 17.36.degree..+-.0.1.degree., 17.78.degree..+-.0.1.degree., 18.40.degree..+-.0.1.degree., 18.93.degree..+-.0.1.degree., 19.52.degree..+-.0.1.degree., 19.80.degree..+-.0.1.degree., 20.07.degree..+-.0.1.degree., 20.65.degree..+-.0.1.degree., 21.49.degree..+-.0.1.degree., 21.71.degree..+-.0.1.degree., 22.23.degree..+-.0.1.degree., 25.38.degree..+-.0.1.degree., 26.15.degree..+-.0.1.degree. and 28.62.degree..+-.0.1.degree..

3. The process of claim 1, wherein said solvent is ethyl acetate.

4. The process of claim 1, wherein said solvent is isopropyl acetate.

5. The process of claim 1, wherein said solvent comprises ethanol and oleic acid.

6. A process of making ritonavir Form I, comprising mixing ritonavir dissolved in ethyl acetate with seed crystals of ritonavir Form I in heptane.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.